手性锌卟啉对咪唑类客体的分子识别及圆二色光谱的研究  

Study on Recognition of Imidazole Derivatives by Chiral Amino Acids Linked Porphyrins and Circular Dichroism Spectroscopy

作　　者：赵小菁[1] 阮文娟[1] 张炎[1] 王树军[1] 南晶[1] 朱志昂[1] 

机构地区：[1]南开大学化学系,天津300071

出　　处：《化学学报》2002年第12期2178-2184,共7页Acta Chimica Sinica

基　　金：国家自然科学基金(No.2 0 1710 2 4);天津市自然科学基金(No.0 2 360 40 11);教育部留学回国人员科研基金资助项目

摘　　要：研究了手性α,α,α,β 四 [邻(叔丁氧羰L 酪氨酸)氨基苯基]卟啉锌[α,α,α,β ZnT(o Boc)TyrTAPP](1)和手性α,α,α,β 四 [邻(叔丁氧羰L 丙氨酸)氨基苯基]卟啉锌[α,α,α,β ZnT(o BocAla)TAPP](2 )对咪唑、2 甲基咪唑、N 甲基咪唑和 2 乙基 4 甲基咪唑的分子识别行为,分别求得主体(1)对咪唑类分子识别的缔合常数顺序为K(Im) >K(2 MeIm) >K(N MeIm) >K(2 Et 4 MeIm),主体(2 )对咪唑类分子识别的缔合常数顺序为K(2 MeIm) >K(Im) >K(2 Et 4 MeIm) >K(N MeIm),并用圆二色光谱(CD)研究了主体 1和 2对咪唑类客体在CHCl3中分子识别的光谱行为。Association constants between alpha,alpha,alpha, beta-ZnT(o -BocTyr) TAPP (1), alpha,alpha,alpha, beta-ZnT(o -BocAla) TAPP (2) and imidazole derivatives were determined in chloroform by means of UV-vis titration method. Association constants of 1 and 2 decreased in sequence K(Im) > K(2-MeIm) > K(N-Melm) > K(2-Et-4-MeIm) and K(2-MeIm) > K(Im) > K(2-Et-4-MeIm) > K(N-MeIm), respectively. Circular dichroism spectra were studied and the results were compared with the thermodynamic of association reaction of this host-guest system.

关 键 词：手性锌卟啉 咪唑类客体 手性分子识别 圆二色光谱 

分 类 号：O657.3[理学—分析化学]