3,4,5-三甲氧基苯甲酰茄呢基胺的合成  

Synthesis of 3,4,5-Trimethoxybenzoylsolanesylamide

作　　者：赵瑾[1] 宋金勇[1] 王超杰[1] 刘蕾[1] 孙心齐[1] 

机构地区：[1]河南大学特种功能材料省重点实验室,开封475001

出　　处：《应用化学》2003年第1期95-97,共3页Chinese Journal of Applied Chemistry

基　　金：河南省科委攻关资助项目 (0 12 40 90 42 1)

摘　　要：Trimethoxybenzoyloxysolanesylamide（8） was first synthesized from solanesol in four steps. Thus, solanesyl bromide（5） prepared by the reaction of solanesol（4） and PBr3 was reacted with potassium phthalimide to give N-solanesylphthalimide（6）, which was refluxed with N2H4·H2O in 95%EtOH to give solanesylamine（7）. Compound 7 was then reacted with 3,4,5-trimethoxybenzoyloxyl chloride to give the title compound. Its structure has been confirmed by IR, 1H NMR, MS and elemental analysis.Trimethoxybenzoyloxysolanesylamide(8) was first synthesized from solanesol in four steps. Thus, solanesyl bromide(5) prepared by the reaction of solanesol(4) and PBr_3 was reacted with potassium phthalimide to give N-solanesylphthalimide(6), which was refluxed with N_2H_4·H_2O in 95%EtOH to give solanesylamine(7). Compound 7 was then reacted with 3,4,5-trimethoxybenzoyloxyl chloride to give the title compound. Its structure has been confirmed by IR, 1H NMR, MS and elemental analysis.

关 键 词：3 4 5-三甲氧基苯甲酰茄呢基胺 合成 茄呢醇 三甲氧基苯甲酰茄呢基胺 有机药物 

分 类 号：TQ463.4[化学工程—制药化工] R914.4[医药卫生—药物化学]