酶法生产7-氨基头孢烷酸的研究进展  

Progress in enzymatic conversion of cephalosporin C to 7-aminocephalosporanic acid

作　　者：罗晖[1] 李强[1] 童忆舟[1] 司颖涛 沈忠耀[1] 

机构地区：[1]清华大学化工系,北京100084

出　　处：《现代化工》2002年第12期18-22,共5页Modern Chemical Industry

摘　　要：氨基头孢烷酸 (7 ACA)是生产头孢菌素的重要原料 ,目前都由头孢菌素C通过化学法或生物酶法生产。综述了利用酶法生产 7 ACA的研究进展 ,其中涉及催化过程所用两种酶 (D 氨基酸氧化酶和GL 7 ACA酰化酶 )的酶学特性、表达、纯化。The 7-aminocephalosporanic acid,a starting compound in the synthesis of cephalosporin antibiotics,is obtained from cephalosporin C by a chemical process or by a two-step enzymatic process.The enzymatic conversion of cephalosporin C to 7-aminocephalosporanic acid by using D-amino acid oxidase and glutaryl-7-ACA acylase is reviewed with details of classification,characteristics,expression,purification,immobilization and conversion technology of the enzymes depicted in it.

关 键 词：酶法 7-氨基头孢烷酸 研究进展 D-氨基酸氧化酶 GL-7-ACA酰化酶 头孢菌素C 

分 类 号：TQ465.1[化学工程—制药化工]