肺癌的立体定向放射治疗  

Stereotactic radiotherapy for pulmonary carcinoma

作　　者：侯宁农[1] 

机构地区：[1]天津市环湖医院外科,300060

出　　处：《中国局解手术学杂志》2002年第4期335-337,共3页

摘　　要：目的 利用立体定向放射治疗肺癌,开辟肺癌治疗新途径。方法 27例病人采用CT定位2mm层厚连续扫描并通过图像重建,计算出临床靶体积(CTV),计划靶体积(PTV)及受累器官体积的照射量-体积直方图。应用德国Leibinger的立体定向系统和Varian 600c加速器进行治疗。结果 本组27例肺癌病人在接受立体定向放射治疗过程中无一例死亡。患者一般评分标准采用Karnofsky(KPS)标准,术前KPS评分20～80分,平均59分,术后KPS评分20～100分,平均87分。随访患者按实体瘤疗效标准:完全缓解(CR)4例,部分缓解(PR)17例,无变化(NC)2例,进展(PD)4例。肿瘤控制有效率85％。结论 立体定向放射治疗肺癌近期疗效良好,且随着临床经验的不断积累,立体定向放射治疗必将在肺癌的综合治疗中占有重要的地位。Objective To explore a new method for treating patients with pulomonary carcinoma by using stereotactic radiotherapy. Methods Twenty - seven patients were treated. The lesions were localized by 2 mm thick and 0 mm interval CT scan. The images were reconstructed and clinical tumor volume (CTV) , planning tumor volume (PTV) and dose - volume histograms of the involved lung were calculated by the computer workstation. Leibinger stereotactic radiotherapy planning system and Varian Clinic 600c were used for treatment. Results None of the patients died in the process of treatment . The KPS score of patients were 20-80 with mean 59 before treatment, and 20 - 100 with mean 87 after treatment. According to the criterion of curative effect of solid tumor follow- up CR 4 patients, PR 17 patients, NC 2 patients and PD 4 patients. The control rate was 85 % . Conclusion Stereotactic radiotherapy provides excellent lesion control in pulmonary carcinoma. It will become an important therapeutic method in the combined treatment of pulmorary carcinoma. .

关 键 词：肺癌 立体定向 放射疗法 治疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.[医药卫生—临床医学]