CT引导下PVP携带化疗药物治疗脊柱转移瘤  

PVP carrying chemotherapeutant to treat spinal metastases by CT guidance

作　　者：陆军[1] 张贵祥[2] 石梅[1] 韩良辅[1] 孙朝阳[1] 王志祥[1] 

机构地区：[1]第四军医大学西京医院放疗科,陕西西安710033 [2]第四军医大学西京医院放射科,陕西西安710033

出　　处：《第四军医大学学报》2002年第24期2271-2274,共4页Journal of the Fourth Military Medical University

摘　　要：目的　探讨经皮穿刺椎体成型术 (PVP)在椎体转移瘤中的作用以及在骨水泥中掺入化疗药物的价值 .方法　将病理证实的椎体转移瘤患者随机分为两组 ,单纯椎体成形术(VSA)组及携带化疗药物椎体成型术 (VACC)组 ,于CT引导下行PVP治疗 .通过疼痛调查表和定期随访观察疗效及并发症 .结果　VSA组有效率 70 .4 % ,完全缓解率 12 .3% ;VACC组有效率 89.5 % ,完全缓解率 2 0 .0 % ;需治疗的不良反应、并发症合计 2 .0 % ,无远期并发症 .结论　PVP是治疗椎体转移瘤微创、简单、有效、并发症少的好方法 ,明显改善生存质量 ,骨水泥中加入化疗药可提高PVP效果 .AIM To investigate the efficacy of the treatment of percutaneous vertebroplasty (PVP) in patients with spinal metastases and to determine the value of the treatment with mixed anti cancer drugs added to the bone cement during PVP. METHODS Patients who were proved to have had spinal metastases by pathological means were divided into two groups at random: one group was treated by vertebroplasty by simple acrylate (VSA) and the other by vertebroplasty by acrylate carrying chemotherapeutant (VACC). The treatment in both groups were guided by CT. The results and complications were evaluated by questionnaire of pain and routine follow ups. RESULTS The efficiency rate and the complete relief rate of VSA were 70.4% and 12.3%, respectively. On the other hand, the efficiency rate and the complete relief rate of VACC were 89.5% and 20.0%, respectively. The total rate of complications which need treat was 2.0% and there were no long term complications in this study. CONCLUSION PVP, a minimally invasive, simple and efficient treatment with fewer complications, can improve the life quality of patients and the effects of PVP can be enhanced by adding mixed chemotherapeutant.

关 键 词：CT引导 PVP 化疗药物 治疗 脊柱转移瘤 

分 类 号：R738.1[医药卫生—肿瘤]