大肠癌患者免疫状态及西咪替丁免疫调节作用的临床研究  

Study of the immunologic effects of cimetidine in patients with colorectal cancers.

作　　者：张宏宇[1] 张才全[1] 郁解非[1] 

机构地区：[1]重庆医科大学附属第一医院,重庆400016

出　　处：《四川医学》2002年第12期1240-1242,共3页Sichuan Medical Journal

摘　　要：目的　初步探讨围手术期使用西咪替丁对大肠癌患者免疫功能的调节作用。方法　采用APAAP法、MTT比色法和ELISA法对随机入选的 40例大肠癌患者 (实验组、对照组各 2 0例 )和 15例正常人外周血的T细胞亚群、NK细胞活性及血清IL 2水平等指标进行测定。结果　大肠癌患者免疫功能明显低于正常人 ;围手术期西咪替丁治疗可改善T细胞亚群的紊乱 ,增强NK细胞活性并提高血清中IL 2水平。Objective To investigate the immunologic effects of cimetidine on patients with colorectal cancers.Methods Cellular immunologic functions were evaluated by immnohistochemical method,MTT assay and ELISA in 40 patients with colorectal cancer who were divided randomly into two groups,one treated perioperatively with 400mg cimetidine twice daily and the another without as control.In addition,15 normal subjects were studied in the same way.Results Cimetidine could improve the immunologic function of patients with colorectal cancer by lessening the disorder in T lymphocytes subgroup and improving the acitivity of natural killer cells and level of IL-2.Conclusion Cimetidine could serve as an important perioperative adjuvant in treatment of colorectal cancer.

关 键 词：大肠癌 西咪替丁 临床研究 围手术期 免疫功能 

分 类 号：R735.34[医药卫生—肿瘤]