DLC1在肿瘤中的研究进展  

Research progress of DLC1 in carcinoma

作　　者：李斌[1] 

机构地区：[1]兰州军区兰州总医院消化内科,甘肃兰州730050

出　　处：《海南医学》2016年第5期792-794,795,共4页Hainan Medical Journal

摘　　要：在癌细胞中,识别基因及其功能的改变对肿瘤的预防与治疗极其重要。大量证据显示抑癌基因(Deleted in liver cancer 1,DLC1),在癌细胞发生及转移的过程作为抑癌基因,其编码的蛋白是一种Rho GTPase的激活剂,可为治疗肿瘤策略提供良好机会。现就DLC1抑制多种肿瘤发生与转移及其调控机制的相关研究进行综述。In cancer cells, the identification of genetic and functional alterations is critical for designing preventive and therapeutic strategies. Evidence showed that the deleted in liver cancer 1(DLC1) acted as a suppressor gene in the genesis and metastasis of cancer cells. Moreover, protein DLC1, a Rho GTPase activator, promises opportunities for therapeutic strategies based on DLC1 function. This review presents evidence supporting an anti-occurrence and metastatic role for DLC1 in human cancers and discusses the mechanisms contributing to its inhibitory effects.

关 键 词：抑癌基因 黏着斑 肿瘤 发生 转移 

分 类 号：R730.2[医药卫生—肿瘤]