血管内皮生长因子在大肠癌组织中的表达及意义  

Significance of Vascular Endothelial Growth Factor Expression in Colorectal Carcinoma

作　　者：蒋成安[1] 

机构地区：[1]苏州大学附属第一医院普外科,苏州215006

出　　处：《中国血液流变学杂志》2002年第4期308-309,共2页Chinese Journal of Hemorheology

摘　　要：目的　探讨血管内皮生长因子 (VEGF)在大肠癌组织中的表达及其与大肠癌生物学行为的关系。方法　应用S -P免疫组化检测 48例人大肠癌组织的VEGF表达 ,分析VEGF与大肠癌组织学类型、分化程度、Dukes分期及淋巴结转移关系 ,并观察VEGF在大肠癌组织不同区域的表达。结果　VEGF表达率随大肠癌Dukes分期的进展而增加 ,且DukesC期的VEGF表达率显著高于DukesA期 (P <0 0 1 )。VEGF在有淋巴结转移组的表达率显著高于无淋巴结转移组 (P <0 0 5) ,而它的表达与组织学类型及分化程度无关 (P >0 0 5) ,VEGF仅在癌细胞内表达 ,在癌旁及正常组织内无表达。结论　VEGF表达对大肠癌的进展有促进作用 。Objective To investigate the expression of vascular endothelial growth factor(VEGF) and its relationship with the progression of colorectal carcinoma.Methods VEGF protein in 48 cases of human colorectal carcinoma was examined with the S-P method and its relations to tumor histologic type, histologic grade, Dukes stage and lymph node metastasis were analyzed.Results VEGF positive rate increased with Dukes stage and the VEGF positive rate in Dukes C stage was significantly higher than that in Dukes A stage. Tumors with lymph node metastasis expressed VEGF significantly higher than tumors without lymph node metastasis. No correlation was found between the VEGF expression and tumor histologic type or histologic grade.Conclusion VEGF promotes the progression of colorectal carcinoma. VEGF expression may serve as a tumor marker to evaluate the biological behavior of colorectal carcinoma.

关 键 词：表达 大肠癌 血管内皮生长因子 VEGF 生物学 

分 类 号：R735.34[医药卫生—肿瘤]