福州市健康儿童口咽部流感嗜血杆菌带菌调查  

The Study on the Oral Pharyngeal Carriage of Haemophilia Influenzae in Healthy Preschool Children in Fuzhou

作　　者：赖国祥[1] 张鸿文[1] 叶礼燕[2] 黄梁浒[2] 林茂英[2] 曹慧琴[2] 陈新民[2] 

机构地区：[1]福州总医院呼吸内科 [2]福州总医院儿科

出　　处：《福州总医院学报》2002年第1期9-11,共3页Journal of Fuzhou General Hospital

摘　　要：目的:了解福州市健康儿童口咽部流感嗜血杆菌(haemophilus influenzae,Hi)带菌情况及菌型特点,提供Hi感染的临床防治依据。方法:选择幼儿园健康日托儿童603名,进行口咽部Hi携带率四季监测,Hi分离株进一步作血清学分型及生物学分型。结果:健康日托儿童口咽部Hi携带率以冬季最高(36.7%),秋季次之(18.0%),春季(10.9%)和夏季(12.4%)相近。Hi分离株血清型秋季以Hib携带率最高(6.9%),冬季以不可分型Hi(NTHi)为主,携带率占17.1%,Hib携带率5.4%,秋、冬季其它各血清型携带率较低。Hi分离株生物型在秋、春、夏季分布较为一致,以生物Ⅶ、Ⅶ型占优势;冬季生物Ⅶ、Ⅶ型明显减少。结论:健康儿童口咽部Hi定殖菌携带率及菌型有季节变迁现象.以冬、秋季Hi携带率较高。提示,在重视Hib结合菌苗接种的同时。应加强Hi新型菌苗的研究。Objective: To investigate the oral pharyngeal carriage and characteristics of haemophilus influenzae(Hi) in healthy preschool children in Fuzhou, and for the clinical prevention and cure of Hi infection. Methods: Take 603 healthy children in two representative kindergartens in Fuzhou as the research subjects, and the oral pharyngeal carriage of Hi were supervised in four seasons. All Hi strains were serotyped and biotyped. ResnltS:The oral pharyngeal carriage of Hi in day-nursed healthy children was 36.7% in winter, 18.0% in autumn, 12.4% in summer and 10. 9% in spring respectively. Serotype Hib was preponderant in autumn(6.9%). In winter, the carriage of NTHi was 17.1%, while Hib was 5.4% . The carriage of other serotypes were low. Biotype Ⅶ and Ⅷ were preponderant in autumn, spring and summer; but in winter biotype Ⅶ and Ⅷ were decreasing evidently. Conclusions: There was evident difference between different seasons in the oral pharyngeal carriage and type of Hi in healthy preschool children. The carriage of Hi strains was high in autumn and winter. The study on new bacterial vaccine of Hi shoud be augmented, while Hib-binding bacterial vaccine should be enhanced.

关 键 词：福州市 流感嗜血杆菌 口咽部流感嗜血杆菌感染 儿童 致病菌 疾病调查 

分 类 号：R781.5[医药卫生—口腔医学] R766[医药卫生—临床医学]