壳聚糖絮凝法制备贞芪扶正口服液  

Study on the preparation process of the chitosan flocculant of the Zhenqi Fuzheng Oral Liquid

作　　者：官东秀 冯祚臻 陈群[2] 赖秀珍[2] 

机构地区：[1]广西玉林市红十字会医院,广西玉林537000 [2]广西桂林医学院,广西桂林541004

出　　处：《沈阳药科大学学报》2003年第1期5-7,共3页Journal of Shenyang Pharmaceutical University

摘　　要：目的优选贞芪扶正口服液的制备工艺。方法采用了正交设计法考察提取时间、次数、加水量及壳聚糖在药液中的浓度 4个因素 ,以黄芪甲苷含量为指标成分。结果壳聚糖絮凝法能代替醇沉法用于贞芪扶正口服液的澄清工艺 ,最佳制备工艺为A1B3C3D3,即选用壳聚糖在药液中浓度为 0 0 7%澄清 ,加药材 8倍量的水提取 3次 ,每次 2h。结论制剂稳定 ;Objective To optimize the preparation procedure for the Zhenqi Fuzheng Oral Liquid.Methods The orthogonal design was used to study the four factors,including extraction time,extraction times,the amount of water added and the concentration of the chitosan in the liquid,taking the content of astragaloside IV as markers.Results The chitosan can be used to the clarification procedure of the Zhenqi Fuzheng Oral Liquid.The optimum extration condition obtained was:A 1B 3C 3D 3.Its concentration of the chitosan in the liquid is 0.07% and extracted by water 3 times,2 h for each time,8 times in all and the water is much as the medicine material.Conclusions The preparation is stable.The method is simple,sensitive,accurate and reproducible.

关 键 词：黄芪甲苷 正交试验法 壳聚糖絮凝法 制备 贞芪扶正口服液 

分 类 号：R284.2[医药卫生—中药学]