N-乙酰基转移酶基因多态性与肝癌易感性的关系  

Relationship between genetic polymorphisms of N-acetyltransferase and susceptibility to hepatocellular carcinoma

作　　者：高建平[1] 黄跃东[1] 朱青川 梁建平[1] 林经安[2] 

机构地区：[1]福建省漳州市中医院检验科,363000 [2]福建医科大学附属第一医院

出　　处：《中华肝脏病杂志》2003年第1期20-22,共3页Chinese Journal of Hepatology

摘　　要：目的探讨N-乙酰基转移酶(NAT2)基因多态性与肝癌易感性的关系。方法应用自动实时荧光Light-Cycler技术,分析78例肝癌患者和112例健康志愿者NAT24个位点的基因多态性,比较肝癌患者与对照组间频率差异。结果 肝癌吸烟组NAT2慢乙酰化基因型频率(37.5％)与对照吸烟组(17.9％)比较差异有显著性(X2=4.67,P<0.05),并使患肝癌的危险度提高了2.76倍;肝癌非吸烟组NAT2慢乙酰化基因型频率(26.3％)与对照非吸烟组(16.1％)比较差异无显著性(X2=1.47,P>0.05)。结论携带NAT2慢乙酰化基因型的吸烟者可能是肝癌的高危人群。Objective To study the possible relationship between genetic polymorphism of N-acetyltransferase 2 (NAT2) and susceptibility to hepatocellular carcinoma. Methods Genetic polymorphisms of the four NAT2 genes in 78 patients with hepatocellular carcinoma and 112 healthy controls were analyzed by means of real-time fluorescence light-Cycler. The difference in frequencies between the hepatocellular carcinoma patients and the controls were compared. Results The significant difference in slow acetylation genotype frequency was found between the controls and the hepatocellular carcinoma patients who were smokers (17.9% vs 37.5%, x2= 4.67, P<0.05) resulting in increased by 2.76 times the risk for hepatocellular carcinoma, but no evident difference between the controls and hepatocellular carcinoma patients who were non-smokers. Conclusion The smokers with slow acetylation genotype of N-acetyltransferase 2 may be the population with high risk for hepatocellular carcinoma.

关 键 词：N-乙酰基转移酶 基因多态性 肝癌 易感性 

分 类 号：R735.7[医药卫生—肿瘤]