p16蛋白在肾母细胞瘤中的表达  

Significance of p16 Protein Expression in Nephroblastoma

作　　者：宋兰云[1] 王学文[1] 胡晓丽[1] 宁培儒[1] 

机构地区：[1]天津市儿童医院病理科,300074

出　　处：《天津医药》2003年第1期23-24,共2页Tianjin Medical Journal

摘　　要：目的:探讨p16蛋白在肾母细胞瘤中的表达及临床意义。方法:应用S-P免疫组织化学方法对42例肾母细胞瘤常规石蜡标本进行p16蛋白检测。结果:42例中p16蛋白表达缺失率为69.05％,p16蛋白阳性表达与病理组织类型、患儿预后显著相关(P<0.01),阳性表达者预后好。结论:p16蛋白表达可作为判断肾母细胞瘤预后的指标。Objective: To study the significance of p16 protein expression in nephroblastoma. Methods: The p16 expression was studied with immunohistochemical method in 42 patients with nephroblastoma.Results:The negative rate of p16 protein expression was 69.05%.The positive rate of p16 protein expression was significantly related to pathological types and prognosis(P<0. 01). The prognosis was better in positive case than that in negative case.Conclusion: The p16 protein expression can be used as a marker to predict the prognosis of nephroblastoma.

关 键 词：肾母细胞瘤 蛋白质P16 免疫组织化学 基因表达 

分 类 号：R737.11[医药卫生—肿瘤]