我院肺癌患者呼吸道真菌感染调查分析  

Clinical Data Analysis of Fungal Infection in Respiratory Tract of Lung Cancer Patients in the Qingdao People Hospital

作　　者：杨鲁民[1] 邢秀民[2] 孙桂枝[1] 王伦青[1] 陈岩[1] 马锴[1] 申少楣[3] 

机构地区：[1]青岛市人民医院胸心外科,266001 [2]青岛市人民医院呼吸内科,266001 [3]青岛市人民医院肿瘤科,266001

出　　处：《临床肺科杂志》2003年第1期31-33,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的　了解肺癌患者呼吸道真菌感染的流行趋势及相关因素。方法　回顾性调查 12 96例肺癌住院患者的呼吸道真菌感染 ,按性别、年龄及治疗方法等进行发病率及病因分析 ,并做统计学处理。结果　 12 96例肺癌患者中呼吸道真菌感染 78例 ,感染率为 6 .0 % ,男性 (7.0 % )明显高于女性 (3.9% ) ,(p<0 .0 5 ) ,各年龄组间及手术组(6 .6 )与非手术组 (5 .5 )间感染率差异无显著性 (p>0 .0 5 ) ,手术组内术前术中接受化疗患者的感染率 (9.8 )高于未化疗的 (5 .2 ,p<0 .0 5 ) ,非手术组内化疗 (6 .8 )和化疗 +放疗患者 (7.6 )的感染率均明显高于单纯放疗 (2 .6 ,p<0 .0 1)和其它治疗患者 (3.4 ,p<0 .0 1) ,感染患者与未感染患者的抗生素使用率及联合用药率的差异均有高度显著性 (p<0 .0 0 1)。结论　肺癌患者呼吸道真菌感染发病率与化疗及长期使用广谱抗生素及性别等因素相关 。Objective To examine the epidemic tendency and the correlated factors related to such tendency about fungal infection in respiratory tract of lung cancer patients.Methods One thousand two hundreds and ninety six hospitalized patients with lung cancer during the period of January 1987 through December 2001 were sampled retrospectively for the study. The patients were classified into subgroups based on their age, sex, and methods of treatment. Prevalence and incidence rates and causes of fungal infection in airway were analyzed accordingly. The data were processed by statistical methods.Results Out of the 1296 patients, 78 (6.0%) were identified as infected with fungus in the airway. The difference of infective rates between man and woman (7.0% and 3.9%, respectively for man and woman groups: p < 0.05), but was not significant (p >0.05) among the age groups and between the operation and non operation groups (6.6% and 5.5%, respectively for the two groups: p>0.05). For the operation group, the patients who had received chemotherapy either before or in the operation had significantly higher infection rate than those who did not receive the chemotherapy: 9.8% vs. 5.2%, p <0.05). For the non operation group, those who received chemotherapy or a combination of chemotherapy and radiotherapy had a higher infection rate than those who received the radiotherapy only: 7.6% vs. 2.6%, p <0.01) and those who received other types of treatment: 7.6% vs. 3.4%, p<0.01). A significantly higher percent of infective patients used antibiotics compared to the uninfective patients: 97.4% vs. 63.3%, p <0.01. Conclusion The fungal infection in respiratory tract of lung cancer patients is related to the use of chemotherapy and wide use of antibiotics for a long time. It is not associated with the patients' age and the status of the operation.

关 键 词：肺癌 真菌感染 呼吸道感染 流行病学 

分 类 号：R734.2[医药卫生—肿瘤]