Clinical significance of plasma tissue factor pathway and urokinase-type plasminogen activator system in cancer patients  

恶性肿瘤患者血浆组织因子及尿激酶型纤溶酶原激活物水平检测的临床意义(英文)

作　　者：赵维莅[1] 王学锋[1] 璩斌[1] 黄霞萍[1] 王鸿利[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海血液学研究所,上海200025

出　　处：《Chinese Medical Journal》2002年第5期702-704,150,共3页中华医学杂志（英文版）

基　　金：ThisstudywasthesupportedbytheClydeWuFoundation ;ShanghaiInstituteofHematology ;Shanghai;China

摘　　要：OBJECTIVE: To evaluate variations in the plasma tissue factor (TF) and urokinase type plasminogen activator (u-PA) system and their relationship with clinical cancer type, pathological classification and metastatic status in cancer patients. METHODS: Plasma levels of TF and its inhibitor (TFPI), as well as u-PA and its receptor (u-PAR) were measured using ELISA in 76 patients with malignant tumors and 24 patients with benign tumors. RESULTS: Plasma levels of TF and u-PAR in the malignant tumor group were significantly higher than those of the benign tumor group and the normal control. U-PA and u-PAR increased significantly in patients with esophageal and gastric cancer. However, most of these parameters except TFPI did not vary according to pathological classification. A significant elevation was evident in patients with local infiltration, lymph node involvement and distal metastasis, while u-PAR only increased in the latter two categories. CONCLUSIONS: Both the TF and u-PA systems are activated in cancer patients. U-PA and its receptor might prove to be a clinically useful marker for disease progression.目的　了解恶性肿瘤患者血浆组织因子 (TF)和尿激酶型纤溶酶原激活物 (u PAR)系统的改变及其与肿瘤种类、病理分型和转移情况的关系。方法　运用ELISA法检测 76例恶性及 2 4例良性肿瘤患者血浆TF及其抑制物 (TFPI) ,u PAR及其受体 (u PAR)水平。结果　恶性肿瘤患者血浆TF和u PAR水平较良性肿瘤组及正常对照组显著升高。食管癌及胃癌患者血浆u PA显著升高。除TFPI外 ,其余三项指标与患者的病理分型无关。局部侵润、局部淋巴结受累及远处转移患者血浆u PA水平与无上述情况的患者组存在明显差异 ,而u PAR在局部淋巴结受累和远处转移患者较无上述情况的患者组显著升高。结论　恶性肿瘤患者体内存在着TF和u PAR系统的激活。U PA及其受体的检测可提示疾病的进程。

关 键 词：ADULT Aged Aged  80 and over Female Humans LIPOPROTEINS Male Middle Aged Neoplasm Metastasis NEOPLASMS Receptors  Cell Surface Research Support  Non-U.S. Gov't THROMBOPLASTIN Urinary Plasminogen Activator 

分 类 号：R730.43[医药卫生—肿瘤]