Experimental studies on the treatment and pathological basis of combined radiation and burn injury  

放烧复合伤的治疗及其病理基础的实验研究(英文)

作　　者：程天民[1] 陈宗荣[1] 阎永堂[1] 冉新泽[1] 粟永萍[1] 艾国平[1] 

机构地区：[1]第三军医大学全军复合伤研究所,重庆400038

出　　处：《Chinese Medical Journal》2002年第12期1763-1766,共4页中华医学杂志（英文版）

基　　金：ThisstudywassupportedinpartbytheNationalBasicResearchandPrioritiesProgram (No G19990 5 42 0 5)

摘　　要：OBJECTIVE: To investigate therapeutics for and the pathological basis of combined radiation and burn injuries. METHODS: Combined radiation and burn injuries on mice and rats were inflicted by gamma ray irradiation from a (60)Co source and thermal radiation from a 5 kW bromotungsten lamp. RESULTS: The dysfunction of myocardium played an important role in the development of early stage shock. Transfusion of irradiated (in vitro, 20 Gy) or stored (4 degrees C, 7 days) blood after irradiation was done to promote the success of allo-transplantation of bone marrow. Decrease of IL-4 mRNA expression was the molecular basis of depression of intestinal mucosa immune and intervention of IL-4 showed an antagonistic effect on enterogenic infection. A new lipid component extracted from burn eschar was documented for the first time and its toxic effects were elucidated. The survival rate of alloskin grafts after removal of burn eschar from the recipient animals was obviously increased in combined injury due to reduction of immune rejection activity by the radiation effect. In contrast, in animal models with simple burn, the alloskin grafts were all rejected within ten days after the procedure. A successful therapeutic result (survival rate: 92% for 30 days and 67% for 100 days) was obtained by comprehensive management of treated animals, while the untreated control animals all died within 3 - 7 days after injury. CONCLUSION: The pathogenesis of injury caused by simultaneous radiation and burn is extremely complicated and the treatment is very difficult. A comprehensive management program consisting of several therapeutic measures aimed at key links of the pathogenesis may achieve significantly improved results.目的　研究放烧复合伤的实验治疗及其病理学基础。方法　昆明种小鼠和Wistar大鼠由6 0 Co源γ射线照射致放射损伤 ,5kW溴钨灯热辐射致烧伤 ,两者合并致复合伤。结果　心肌功能损害在早期休克的发生发展中有重要作用。受照射后输入照射血 (体外照射 2 0Gy)或贮存血(4℃ ,7天 )促进异体骨髓移植成功。肠淋巴组织IL 4mRNA表达受抑是肠黏膜免疫降低的分子基础 ,IL 4能有效降低肠源性感染的发生。从烧伤焦痂中首次分离到一种新的脂质成分 ,我们初步揭示其毒性效应。放射损伤抑制排异反应 ,从而显著提高早期切痂后所植异体皮的活存率 ;而单纯烧伤组所植异体皮于 10天前全部发生排异。综合治疗后极重度放烧复合伤 (不治疗于伤后 3- 7天内全部死亡 ) 30天存活率为 92 % ,10 0天存活率为 67%。结论　放射损伤合并烧伤后 ,发病机制十分复杂 ,治疗甚为困难。经针对发病关键环节的综合治疗 。

关 键 词：ANIMALS BURNS Calcium Heart HEMATOPOIESIS Mice Radiation Injuries RATS Rats  Wistar Research Support  Non-U.S. Gov't 

分 类 号：R64[医药卫生—外科学]