Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis  

阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察(英文)

作　　者：柴君杰[1] 孟贺巴特[1] 焦伟[1] 孙德玉[1] 梁斌[1] 石劲草[1] 付承[1] 李雄[1] 毛一丁[1] 王秀玲[1] 多力坤[1] 古丽拜尔[1] 王燕春[1] 高芳华[2] 肖树华[2] 

机构地区：[1]新疆地方病防治研究所,乌鲁木齐830002 [2]中国预防医学科学院寄生虫病研究所,上海200025

出　　处：《Chinese Medical Journal》2002年第12期1809-1813,148,共5页中华医学杂志（英文版）

基　　金：ThisstudywassupportedbytheNinthNationalFive yearPlanKeyResearchProject (No .96 90 6 0 4 0 9)

摘　　要：OBJECTIVE: To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis. METHODS: Two regimens of AbzE (10 mg.kg(-1).d(-1) and 12.5 mg.kg(-1).d(-1)) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1 - 4 years after the cessation of therapy. RESULTS: At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.1%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg.kg(-1).d(-1) for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results. CONCLUSIONS: AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.目的　验证新剂型阿苯达唑乳剂对肝囊型包虫病患者的临床疗效。方法　对 2 12例肝囊型包虫病患者用阿苯达唑 10mg/Kg/d和 12 5mg/Kg/d两种剂量进行治疗。服药 3个月复查一次为一个疗程 ,各疗程之间不间断连续用药。以B超影象特征为主判定疗效。观察不同疗程的效果。以停药时的检查结果为近期疗效。停药后随访 1- 4年的结果为远期疗效。结果　两个剂量组共 2 12例患者的平均近期疗效为 :治愈率 74 5 % ,有效率为 99 1% ,无效率为 0 9%。平均远期疗效为 :治愈率为 83 1% ,有效率为 89 3% ,无效率为 0 6% ,复发率为 10 2 %。以 12 5mg/Kg/d连续治疗 9个月的疗效最好。复发病人再治疗的效果良好。结论　阿苯达唑乳剂对肝囊型包虫病的临床疗效超过当前包虫病药物治疗的最好水平。且疗效稳定可靠 ,不良反应轻微。可做为包虫病首选治疗方法。

关 键 词：Adolescent Adult Aged Aged  80 and over ALBENDAZOLE CHILD Child  Preschool Echinococcosis  Hepatic Emulsions Female Humans Male Middle Aged Research Support  Non-U.S. Gov't 

分 类 号：R532.32[医药卫生—内科学]