Effect of glucocorticoid treatment on insulin like growth factor-Ⅰ and its binding proteins in children with nephrotic syndrome  

强的松治疗对肾病综合征儿童血清IGF-Ⅰ及IGFBPs的影响(英文)

作　　者：董峰[1] 周湘[1] 庞宁[1] 魏珉[2] 

机构地区：[1]中日友好医院儿科,北京100029 [2]北京协和医院儿科,北京100730

出　　处：《Chinese Medical Journal》2002年第9期1383-1385,共3页中华医学杂志（英文版）

摘　　要：Objective To identify the changes in serum insulin like growth factor Ⅰ (IGF Ⅰ) and IGF binding proteins (IGFBPs) in children with nephrotic syndrome (NS) and the effect of glucocorticoid on serum IGF Ⅰ and IGFBPs Methods We measured serum IGF Ⅰ and IGFBPs levels by radioimmune assay and immune radiomagnetic assay in 36 children with NS, consisting of an active stage group (ANS, n=12), a remission stage group (RE, n=12), an active stage group with glucocorticoid treatment (GNS, n=12), and a normal control group (NC, n=10) Results 1) Compared to NC, serum levels of IGF Ⅰ and IGFBP 3 were decreased ( P <0 01); serum levels of IGFBP 1 and IGFBP 2 were increased ( P <0 01) in the ANS group 2) Serum levels of IGF Ⅰ and IGFBP 3 were higher and IGFBP 1 and IGFBP 2 were lower in the RE Group than in theANS Group ( P <0 01) 3) Compared to the ANS group, serum levels of IGF Ⅰ and IGFBP 3 were increased ( P <0 01) and serum levels of IGFBP 1 and IGFBP 2 were decreased ( P <0 01) in the GNS group 4) A correlation was found between serum levels of IGFBP 3 and albumin in the active stage group ( r =0 76, P <0 01) There was also a correlation between serum levels of IGF Ⅰ and IGFBP 3 and an inverse correlation between the serum level of IGF Ⅰ and serum levels of IGFBP 1 and IGFBP 2 in the ANS group No other correlations were observed Conclusions The serum levels of IGF Ⅰ and IGFBPs are altered in children in the active stage of NS, but return to normal in the remission stage GC treatment may influence serum IGF Ⅰ and IGFBPs in children with NS Changes in IGF Ⅰ and IGFBPs levels may play a role in the growth retardation of NS children目的　了解儿童肾病综合征 (NS)及糖皮质激素 (GC)治疗对血清胰岛素样生长因子 Ⅰ (IGF Ⅰ )及其结合蛋白(IGFBPs)的影响。方法　采用免疫放射法对 36名NS患儿 ,即未治疗的活动期组 (ANS ,12例 ) ,强的松治疗中活动期组 (GNS ,12例 )和缓解期组 (RE ,12例 ) ,进行了血清IGF Ⅰ及其IGFBPs水平测定 ,并以同年龄组正常儿童作对照 (NC ,10例 )。结果　 (1)与正常对照比较 ,NS活动期血清IGF Ⅰ和IGFBP 3明显降低 (P <0 0 1) ,而IGFBP 1和IGFBP 2均明显升高 (P <0 0 1) ;(2 )NS缓解期血清IGF Ⅰ和IGFBP 3明显高于活动期 (P <0 0 1) ,而IGFBP 1和IGFBP 2明显低于活动期 (P <0 0 1) ;(3)经激素治疗的活动期组血清IGF Ⅰ和IGFBP 3均明显高于未治疗活动期组 (P <0 0 1) ,IGFBP 1和IGFBP 2水平也明显低于ANS组 (P <0 0 1) ;(4)NS活动期血清IGFBP 3与ALB成正相关 (r=0 76 ,P<0 0 1) ,血清IGF Ⅰ与IGFBP 3成正相关 ,而与IGFBP 1、IGFBP 2成负相关。在缓解期及激素治疗中的活动期血清IGF Ⅰ及IGFBPs与ALB及CHO没有相关关系。结论　 1)儿童肾病综合征活动期血清IGF Ⅰ和IGFBPs发生明显改变 ,这种改变在缓解期可恢复正常。 2 )糖皮质激素治疗对肾病综合征儿童血清IGF Ⅰ和IGFBPs有明显影响。 3)肾病综合征儿童?

关 键 词：nephrotic syndrome ·glucocorticoid · insulin  like growth factor  Ⅰ · insulin  like growth factor   binding proteins 

分 类 号：R726.9[医药卫生—儿科]