凝血酶原基因G20210A变异与深静脉血栓关系的研究  

Study on the relation between the prothrombin G20210A mutation and deep-vein thrombosis.

作　　者：贺颖[1] 齐华[1] 连建华[1] 郑红[1] 游文凤[1] 

机构地区：[1]郑州大学基础医学院遗传教研室,450052

出　　处：《中国优生与遗传杂志》2002年第6期19-21,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨凝血酶原基因G2 0 2 1 0A变异与中国人群深静脉血栓 (DVT)形成的关系。方法　运用PCR -RFLP方法在 1 0 3例静脉血栓患者与 1 0 6例正常对照中检测凝血酶原基因G2 0 2 1 0A突变情况。结果　在 1 0 3例静脉血栓患者与 1 0 6例正常对照中均未发现一例凝血酶原基因G2 0 2 1 0A突变的个体。结论　国际公认的静脉血栓形成危险因子G2 0 2 1 0A突变不足成为中国人群静脉血栓患者的危险因素。Objective: Our study try to explore the role of the G20210A mutation (G to A subsitution at nucleotide position 20210) in the prothrombin gene in the pathogenesis of deep venous thrombosis in China .Methods: G20210A mutation was detected by PCR-RFLP method. The subjects included 103 patients with deep venous thrombosis and 106 healthy blood donors(control).Results: No G20210A mutation was detected in 103 patients of DVT and in 106 control.Conclusion: Maybe it isn't the main cause of thrombophilia in Chinese. The G20210A mutation in prothrombin gene varied in different regions and races.

关 键 词：深静脉血栓 凝血酶原基因 基因突变 PCR-RFLP 危险因子 

分 类 号：R543[医药卫生—心血管疾病]