自然流产夫妇中新发现的四例世界首报核型  

Four new abnormal karyotypes in couples with spontaneous abortions which were first reported in the world.

作　　者：张晓云[1] 李永全[1] 周汝滨[1] 廖霞[1] 陈小萍[1] 

机构地区：[1]广东医学院医学遗传学研究室,524023

出　　处：《中国优生与遗传杂志》2002年第6期56-57,F004,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　分析自然流产与染色体异常的关系。方法　运用外周血淋巴细胞培养法检测自然流产夫妇双方的染色体核型。结果　发现 4种新的平衡易位的人类染色体异常核型 ,分别为 46 ,XX ,t(1 ;6) (q31 ;p2 5) ;46 ,XX ,t(4;5) (q2 5 ;p1 3) ;46 ,XY ,t(5 ;1 5) (p1 3 ;q1 5) ;46 ,XY ,t(1 0 ;1 1 ) (p1 3 ;q2 1 ) ,经鉴定确定为世界首报核型。结论　染色体异常是导致自然流产的原因。Objective:To analyze the connection between abnormal chromosome and spontaneous abortion.Method:To analyze the chromosome type of circular lymphocytes in couples with spontaneous abortions.Result:Four new balanced translocation karyotypes were discovered,they are 46,XX,t(1;6)(q31;p25);46,XX,t(4;5)(q25;p13);46,XY,t(5;15)(p13;q15);46,XY,t(10;11)(p13;q21)and they were first reported in the world.Conclusion:Chromosome abnormality is the reason of spontaneous abortions.

关 键 词：自然流产 染色体异常 核型 外周血淋巴细胞培养法 

分 类 号：R714.21[医药卫生—妇产科学]