人类基因治疗的背景与肝癌基因治疗的研究概况  

The Background and History of Human Gene Therapy and Advances in the Study of Gene Therapy of Human Hepatocellular Carcinoma

作　　者：黄建钊[1] 顾红光[1] 夏穗生[2] 

机构地区：[1]第三军医大学附属大坪医院肝胆外科,重庆,400042 [2]华中科技大学同济医院器官移植研究所,武汉,430041

出　　处：《中国普外基础与临床杂志》2003年第1期83-85,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　了解人类基因治疗的背景与肝癌基因治疗的研究概况。方法　采用文献复习的方法对人类基因治疗的临床研究历史与发展 ,以及肝癌基因治疗方面的一些基础研究进展进行综述和分析。结果　基因治疗作为人类某些遗传疾病的替代治疗方法在临床研究中已取得了较好效果 ,但在肿瘤的治疗研究中基本上还处于基础研究阶段。在肝癌的基因治疗研究中 ,所有的病毒载体如逆转录病毒、腺病毒以及腺病毒的相关病毒各有优缺点 ,逆转录病毒如能提高滴度 ,应该更有前景 ;所用目的基因TK及p53基因等已在体外及动物实验中取得了较好的效果 ,但在治疗的特异性和安全性方面还存在较大的缺陷。结论　人类基因治疗的前景是乐观的 ,肝癌的基因治疗研究也取得了一定成果 。Objective To know the background of human gene therapy and the advances in gene therapy study of human hepatocellular carcinoma (HCC). Methods The related literatures were reviewed. Results As a substitute measure gene therapy was of great superiority and had got a good result in the clinical study of treatment of human genetic diseases. But it was mainly limited to the study of preclinical phase when it was used to the treatment of tumor. As a carrier of gene transfer, the newly modified retrovirus might have superiority in the study of gene therapy of HCC when compared with other viruses such as adenovirus and adeno associated virus (AAV). The genes TK,p53 and p16 etc. had been used to the study of therapy of HCC and had some good results.Conclusion The future of human gene therapy is optimistic, but there is a long way to go when gene therapy is widely used in the clinical study of treatment of HCC.

关 键 词：基因治疗 肝癌 抑癌基因 

分 类 号：R735.7[医药卫生—肿瘤]