亲代谢型谷氨酸受体配基对黑质6-羟基多巴损毁大鼠的抗氧化作用  

Antioxidation of metabotropic glutamate receptors ligand on unilateral substantia nigral 6-hydroxydopamine lesioned rat

作　　者：顾兵[1] 张颖冬[1] 胡刚[2] 

机构地区：[1]南京医科大学附属脑科医院,南京210029 [2]南京医科大学神经科学研究所,南京210029

出　　处：《中国药理学通报》2003年第1期41-44,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目 No 39970 84;教育部优秀青年教师资助计划项目 (2 0 0 0年 )

摘　　要：目的　探讨亲代谢型谷氨酸受体 (mGluRs)配基对帕金森病 (PD )模型大鼠的抗氧化作用。方法　采用 6 羟基多巴单侧黑质损毁建立帕金森病大鼠模型 ,应用化学比色法测定血清总抗氧化能力 (T AOC)、抑制活性氧能力 (ROS)和谷胱甘肽 (GSH )含量。结果　与模型对照组相比 ,Ⅰ组mGluRs拮抗剂 (SIB 1893 ) ,Ⅱ组mGluRs激动剂 (APDC) ,Ⅲ组mGluRs激动剂 (L SOP )和L DOPA均能增加血清T AOC和GSH水平 ,提高清除ROS能力 ,尤以APDC组作用最明显。结论　Ⅰ组mGluRs拮抗剂和Ⅱ、Ⅲ组mGluRs激动剂对 6 羟基多巴损毁大鼠具有部分抗氧化功能 。AIM To explore the antioxidation of metabotropic glutamate receptors (mGluRs)ligand on rat models of Parkinson disease. METHODS The rat models of Parkinson disease were established by employing 6 hydroxydopamine to lesion unilateral substantia nigral. The serum total antioxidative capability (T AOC), reactive oxygen species (ROS) inhibition competence and content of glotathione (GSH) were measured with chemical colorimetry. RESULTS Compared with control group, serum T AOC and GSH and ROS inhibition competence increased in all treatment groups, mGluRs antagonist (SIB 1893) group, mGluRs agonists (APDC ) group, mGluRs agonists ( L SOP) group and L DOPA group. The effect of APDC was most prominent. CONCLUSION mGluRs antagonist and mGluRs agonists may exert a partial antioxidation effect on unilateral substantia nigral 6 hydroxydopamine lesioned rat and may be beneficial to the body for alleviating the oxdative stress.

关 键 词：亲代谢型谷氨酸受体 帕金森病 抗氧化作用 活性氧 谷胱甘肽 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R965[医药卫生—临床医学]