奥丹西隆对小鼠吗啡身体依赖性的影响  

Effects of ondansetron on morphine physical dependence in mice

作　　者：谢和辉[1] 徐美林[1] 余涓[1] 陈崇宏[1] 俞昌喜[1] 

机构地区：[1]福建医科大学药理学教研室,福州350004

出　　处：《中国药理学通报》2003年第1期56-59,共4页Chinese Pharmacological Bulletin

基　　金：福建省自然科学基金资助项目 No 94A0 0 6

摘　　要：目的　观察 5 HT3受体特异性拮抗剂奥丹西隆 (on dansetron ,Ond)对吗啡身体依赖性的影响。方法　采用小鼠吗啡依赖模型及离体豚鼠回肠吗啡依赖模型。结果　奥丹西隆 12d预防性给药可有效抑制小鼠吗啡戒断反应 ,使其体重降低减小 (Ond 2～ 10 0 μg·kg-1·d-1组 ) ,或体重降低 ,跳跃反应均明显减弱 (Ond 10 0 μg·kg-1·d-1组 )。另外 ,奥丹西隆 (1～ 2 0 μmol·L-1)亦可抑制纳洛酮促发的离体豚鼠回肠收缩。作用均呈剂量依赖性。AIM To investigate the effects of ondansetron, a selective 5 Hydroxytryptamine3 (5 HT 3) receptor antagonist, on morphine physical dependence. METHODS The morphine dependent models in mice and in isolated Guinea pig ileum were used. RESULTS Pretreatment of ondansetron for 12 days significantly reduced morphine withdrawal symptoms in mice ,such as body weight loss(Groups 2～100 μg·kg -1 ·d -1 ) or reduced both body weight loss and jumping times (Group 100 μg·kg -1 ·d -1 ). In addition, concomitant treatment with ondansetron(1～20 μmol·L -1 ) dose dependently suppressed the contraction induced by naloxone in Guinea pig ileum. CONCLUSION The chronic pretreatment of ondansetron can prevent morphine physical dependence to some extent.

关 键 词：奥丹西隆 吗啡 身体依赖 

分 类 号：R749.61[医药卫生—神经病学与精神病学] R971.2[医药卫生—临床医学]