人体内鼻咽癌细胞侵袭特征的电镜观察  

Electron Microscopic Observation on Morphological Charateristics of Invasion of Human Nasopharyngeal Cancer Cells in Vivo

作　　者：王福熙[1] 彭隆祥[2] 朱小京[2] 

机构地区：[1]上海医药工业研究院电镜室 [2]湖南医科大学电镜室

出　　处：《电子显微学报》1992年第1期1-4,共4页Journal of Chinese Electron Microscopy Society

摘　　要：本文采用54例活检和5例尸检的鼻咽部组织,从不典型增生、鼻咽癌的癌旁组织、微小浸润癌及鼻咽癌颅底侵犯等不同情况,在电镜下着重观察癌细胞的侵袭方式。观察证明间变细胞和癌细胞的侵袭方式类似阿米巴的阿米巴运动,其假足穿过缺损的基底层侵入癌旁组织。This article describes the morphological charateristies of nasopharyngeal cancer cells invasion proved by electron microscopy. The results suggested that the processes of invasion of the nasopharyngeal cancer cells can be divided into three stages, namely:a, the cytoplasmic base of anaplasia cells or cancer cells extended numerous filopodia, the latter lead tO waves or/and local loss of basement membrane, then, cancer cells by thire pseudopodia through defective basement membrane penetrated into the underlying interstitial stroma; b, because cancer cells possess capable of ac-tive locomotion, the invading cancer cells by amiboid movement actively migrate into the direction of least resis-tance, and the cancer cells will proliferate when active translatory movement cease, such migration/proliferation cy-cle is repeated, and the tissue pressure proliferating tumor lead to degradation of surrounding tissues; C, the in-vading cancer cells penetrated wall of vessels for further distant metastasis, therefore invasion is an essential part of the metastatic process.

关 键 词：鼻咽癌 细胞 侵袭 电镜 

分 类 号：R739.63[医药卫生—肿瘤]