事件相关功能磁共振成像研究及其在认知神经科学研究中的运用  

Event-related functional magnetic resonance research and its implications for cognitive neuroscience

作　　者：薛贵[1] 董奇[1] 张红川[1] 

机构地区：[1]北京师范大学心理学院脑与认知科学研究所

出　　处：《中国神经科学杂志》2003年第1期45-49,共5页

基　　金：国家攀登项目 (95 专 0 9)资助

摘　　要：事件相关设计的出现和不断发展是近年来功能磁共振成像研究中的一个最新趋势。与传统的区块设计相比 ,事件相关设计能够更灵活地安排实验刺激 ,更好地排除无关刺激的干扰 ,对磁共振信号进行更好的描述。同时也能够进行事后的分类统计并与其他研究手段进行更好地整合 ,从而大大地提高了功能磁共振成像研究探讨问题的广度和深度。随着事件相关设计的不断发展 ,其在认知神经科学研究中得到日益广泛的运用 ,并在感知觉 ,注意 ,记忆 ,思维 ,语言和其他高级功能的脑机制研究中取得了很多具有重要意义的成果。In recent years, event related fMRI (efMRI) has greatly expanded the range as well as the profundity of current researches on cognitve neuroscience with its increasingly widespread application in this field. Compared to traditional block design, efMRI design has many methodolgical advantages, including the flexibility in arranging and presenting stimulus, the high efficiency in excluding the influence of irrelevent factors and the accurracy in describing the profile of blood oxygen level dependent (BOLD) signal. In addition, in efMRI design, the trials can be categorized pos hoc, and the result is more easy to be compared with and integrated into that of EPRs, dichotic listening and half visual fields presentation. Above all of this, the efMRI itself has experienced a drastic development in recent years. For all these merits, efMRI has been wildly adopted by current researches on cognitive neuroscience, and thus has resulted in many important findings in the brain mechanism underling perception, attention, memory, thinking, language and other high level cognitive functions.

关 键 词：事件相关设计 功能磁共振成像 区块设计 认知神经科学 

分 类 号：R445.2[医药卫生—影像医学与核医学]