大鼠脾不统血模型血浆和子宫6-K-PGF_(1α)、TXB_2变化的研究  

Research of Serum and Uterus 6-K-PGF_1α,TXB_2 of Model Rats of Spleen Fails to Be in Charge of Blood Syndrome

作　　者：陈家旭[1] 瞿德竑[1] 季绍良[1] 唐已婷[1] 徐洪雁[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国医药学报》2002年第12期726-728,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局资助课题;高等学校博士基金

摘　　要：目的:观察比较脾气虚证模型、脾不统血证模型与单纯出血因素及卵巢摘除大鼠血浆、子宫PG的变化。方法:以放射免疫法检测上述模型大鼠血浆、子宫6-酮-前列腺素F_(1α)(6-K-PGF_(1α))和血栓素B_2(TXB_2)。结果:各种造模因素均导致血浆、子宫6-K-PGF_(1α)/TXB_2升高,机体表现为出血倾向。结论:6-K-PGF_(1α)/TXB_2比值升高可能是脾不统血证出血的机理之一。Aim: To observe and compare the change of serum and uterus PG betvveen the modei of spleen - qi defi-ciency syndrome, spleen failing to be in charge of blood syndrome and simple hemorrhagic factors and ovariotomy rats. Method: Radio - immunity method was applied to measure the serum and uterus 6 - K - PGF1αand TKB2 of above - noted modei rats. Result: The above - mentioned induced - modei factors all can result in the increase of serum and uterus 6 -K - PGF1α/TXB2 and hemorrhagic tendency of rats. Conclusion: The ratio increase of 6 - K - PGF1α/TXB2 is likely to be one of important mechanisms of hemorrhage in ' spleen fails to be in charge of blood' syndrome.

关 键 词：脾气虚证 脾不统血证 卵巢摘除 前列腺素 

分 类 号：R228[医药卫生—中医基础理论]