食管癌放射治疗的时间、剂量与预后关系  

The Relationship among the Time,Dose and Prognosis of Radiotherapy for Esophageal Carcinoma

作　　者：邹长林[1] 胡美龙[1] 

机构地区：[1]温州医学院附属第一医院放射治疗科,325000

出　　处：《中国卫生统计》2002年第6期339-341,共3页Chinese Journal of Health Statistics

摘　　要：目的　探讨食管癌放射治疗的时间、剂量与预后关系。方法　对食管癌放射治疗的生物有效剂量、总疗程与 1、3年生存率关系进行趋势面分析。结果　三阶趋势面拟合优度为最佳。生物有效剂量 55～ 60Gy,总疗程 3 5～4 5周 ;生物有效剂量 70Gy～ 80Gy,总疗程 4 5～ 5 5周 ,生存率处于一稳定平台。生物有效剂量 66～ 70Gy ,总疗程 3 5～4 0周 ;生物有效剂量 72～ 80Gy ,总疗程 4 1～ 4 4周 ,存在较高的生存率。 结论　三阶趋势面函数可较好解释食管癌放射治疗的生物有效剂量、总疗程与 1、3年生存率关系 。Objective To probe the relationship among the time,dose and prognosis of radiotherapy for esophageal carcinoma.Methods By means of trend surface analysis of the relationship among biologically effective dose(BED),treating course and 1,3 year survival rate of radiotherapy for esophageal carcinoma.Results 3rd steps trend surface analysis can fit properly. The survival rate can be found in a steady stage, within the interval of BED of 55～60Gy and treating course of 3 5～4 5 weeks,and BED of 70～80Gy and treating course of 4 5～5 5 weeks.The relatively high survival rate can be witnessed within the interval of BED of 66～70Gy and treating course of 3 5～4 0 weeks,and BED of 72～80Gy and treating course of 4 1～4 4 weeks.Conclusion The 3rd steps trend surface functions can explain the relationship among BED,treating course and 1,3 year survival rate of radiotherapy for esophageal carcinoma,and it consititute a solid fundation for making radiotherapy treating plan for esophageal carcinoma.

关 键 词：食管癌 放射治疗 时间 剂量 预后 趋势面分析 

分 类 号：R735.1[医药卫生—肿瘤]