9-顺维甲酸对肺鳞癌细胞生长、分化及凋亡的作用  

EFFECTS OF 9-CIS-RETINOIC ACID ON BIOLOGICAL CHARACTERISTICS OF LUNG SQUAMOUS CANCER CELLS

作　　者：张世国[1] 于雪艳[2] 孔立新[1] 鲁秀华[1] 田克力[2] 

机构地区：[1]济南军区总医院 [2]山东大学生物化学与分子生物学研究所

出　　处：《解放军医学杂志》2003年第1期73-75,I002,共4页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金资助课题 (编号 39770 7730 )

摘　　要：为探讨 9 顺维甲酸(9 cisRA)对肺鳞癌细胞的生物学作用 ,应用流式细胞术等对 9 cisRA处理前后L78和A2 两肺鳞癌细胞株的生长、分化和凋亡等特性进行检测观察。结果显示 ,9 cisRA对两肺癌细胞株的生长产生明显的抑制作用 ;应用 9 cisRA后 ,两株细胞分化特征明显 ;经 9 cisRA处理后的两肺鳞癌细胞凋亡率明显高于对照组。研究表明 ,9 cisRA具有抑制肺鳞癌细胞的生长、诱导其分化和凋亡等生物学作用。To study effects of 9 cis retinoic acid (9 cisRA) on biological characteristics of lung squamous cancer cells, cell growth, cell differentiation and apoptotic indexes were observed in 9 cisRA treated L 78 and A 2 lung squamous cancer cells with flow cytometry. The results showed that 9 cisRA exerted marked inhibitory effect on the growth of two lung squamous cancer cell lines, 9 cisRA also had significant inducing effect on the differentiation of L 78 and A 2 cell lines, whereas the percentages of apoptosis of two cell lines in the treatment group were significantly higher than the control group. We conclude that 9 cisRA could inhibit growth inhibition, induce cell differentiation and apoptosis of L 78 and A 2 lung squamous cancer cells

关 键 词：9-顺维甲酸 肺鳞癌 细胞生长 分化 细胞凋亡 

分 类 号：R734.2[医药卫生—肿瘤]