雌二醇对拟痴呆小鼠学习记忆功能的影响  

The effects of estrogen on learning and memory of mouse Alzheimer disease model induced by AlC_l3

作　　者：顾饶胜[1] 沈楠[1] 王艳春[1] 吴晓东[1] 刘微[1] 都培双[1] 

机构地区：[1]解放军第四军医大学吉林军医学院药理教研室,吉林省吉林市132013

出　　处：《中国临床康复》2003年第1期36-37,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:在氯化铝(AlCl3)所致拟痴呆动物模型基础上,探讨雌二醇对拟痴呆小鼠记忆功能保护作用及其作用机制。方法:皮下注射AlCl370mg/d共7d,实验组腹腔注射雌二醇0.3,0.6,0.9mg/kg共20d后,用跳台、避暗等实验方法测定小鼠学习记忆能力,同时测定小鼠脑内乙酰胆碱脂酶(AchE)及脑B型单胺氧化酶(MAO-B)的含量。结果:AlCl3所致痴呆小鼠记忆能力明显降低,表现为避暗、跳台实验的错误次数明显增加,以及增加脑MAO-B含量及脑内AchE的含量,雌二醇各剂量组能够减少小鼠电击次数(错误次数),24h重复实验,可延长跳下平台的潜伏期及进入暗箱的潜伏期,错误次数明显减少。同时降低了脑内AchE和MAO-B。结论:雌二醇对AlCl3所致痴呆小鼠记忆障碍具有保护作用,能增强学习记忆能力。AIM:To study the protective effects and mechanism of estrogen on brain memory obstruction of mouse Alzheimer disease(AD) model induced by AlCl3. METHODS:After sc AlCl3 70 mg/kg for 7 d and estrogen 0.3, 0.6, 0.9 mg/kg for 20 d, using step down test and step through test examined the ability of learning and memory of mice and measurede AchE and MAO B in mouse brain. RESULTS:Estrogen could prolong latency of mouse's step down and latency of entering dark cabin, reduced wrong times and frequency after 24 hours, inhibit activities of AchE and MAO B. CONCLUTION:Estrogen has protective effects on brain learning and memory of mouse AD model induced by AlCl3.

关 键 词：雌二醇 痴呆 小鼠 学习记忆功能 

分 类 号：R749.1[医药卫生—神经病学与精神病学]