精神分裂症患者额叶至杏仁核径路中电阻值变化规律的观察  

Observation of electric impedance on path to amygdala from frontal lobe in patients with schizophrenia

作　　者：李涛[1] 王晓峰[1] 李拴德[1] 姜克明[1] 杨来启[2] 

机构地区：[1]解放军第三医院神经外科,陕西宝鸡721004 [2]解放军第三医院精神科,陕西宝鸡721004

出　　处：《第四军医大学学报》2003年第1期54-55,共2页Journal of the Fourth Military Medical University

基　　金：全军临床高新技术重大项目和全军医学科研"十五"计划面上项目A类 (0 1MA0 1 9)

摘　　要：目的 :研究精神分裂症患者立体定向毁损杏仁核手术径路中所测电阻值的变化规律及其辅助定位意义 .方法 :对 12 0例精神分裂症患者的额叶和手术径路中及杏仁核的电阻值进行测定 ,计算手术径路中及杏仁核的电阻值与额叶皮质的差值 ,将差值与额叶阻值之比进行统计学处理 .结果 :12 0例患者手术径路中的电阻值和额叶皮质阻值的差值与额叶皮质阻值比值 95 %的分布区间为 - 0 .0 2 10± 0 .0 0 5 2 (α =0 .0 5 ) ,杏仁核的阻值为 :(5 5 6± 84 )Ω ,白质的电阻值高于灰质 ,在近靶点 18～ 8mm位置有一高阻值区 ,该区与杏仁核之间阻值及差值比曲线下降明显 .结论 :阻值比值曲线可以反映手术径路中的阻值变化的趋势 ,该曲线稳定、可靠 .杏仁核阻值及邻近靶点高阻值区是接近杏仁核的特征 ,曲线下降明显的部分在手术中可以作为确定杏仁核位置的参考 .AIM: To study the electric impedance on path to amygdala from frontal lobe in patients with schizophrenia, its changes, law, description method and clinic significance. RESULTS: The ratio distribution area was -0.0210 ±0.0052 and the average electric impedance of amygdala was (556±84) Ω, The electric impedance of the white matter was higher than that of the gray matter. The ratio was high between 18 mm and 8 mm near amygdala, then dropped sharply. CONCLUSIONS: The ratio curve is useful in the description of the tendency of change in electric impedance and it could be helpful to locating amygdala in stereotactic operation.

关 键 词：精神分裂症 额叶 杏仁核 电阻值 立体定向射频核团毁损术 

分 类 号：R749.3[医药卫生—神经病学与精神病学]