Hypokalemia as an early index in trimethyltin chloride poisoning  

作　　者：TangXJ LiLY 

机构地区：[1]GuangdongPreventionandTreatmentCenterforOccupationalDisease,Guangzhou510300,China

出　　处：《中国药理学与毒理学杂志》2002年第6期417-418,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：Nowdays,dimethyltin(DMT) is widely used as plastic stabilizers.Trimethyltin chloride(TMT) is the main byproduct of DMT.Our study on SD rats had shown that hypokalemia played a very inportant role in TMT poisoning.The purpose of this paper was to clarify if hypokalemia can be used as an early index of diagnosis,therapy and prevention in TMT intoxication.We analyzed the serum potassium of 169 cases exposed to TMT,from which 123 cases were measured in 24h after the disease was complained.The serum potassium of 96 cases(78%) were below 3.5mmol·L^-1.Four cases died with very serious hypokalemia(<2.5mmol·L^-1).The lower the serum potassium was,the more serious of symptom would be found.In the recent 3 accidents,we measured the serum potassium as early as possible,and treat with KCl(iv or po) rightly.All of the 95 cases recovered within 1 month.No sequela was found.The available evidence suggested that hypokalemia could be the early clinical signs of TMT intoxication.Injection of KCl early should be the first selected treatment.

关 键 词：低血钾 慢性中毒 早期指标 三甲基锡 TRIMETHYLTIN 

分 类 号：R996.1[医药卫生—毒理学]