中国人胶质瘤中表皮生长因子受体基因的扩增及对患者预后的影响  

Amplification of epidermal growth factor receptor (EGFR) gene in Chinese gliomas and its influence to prognosis

作　　者：周颖奇[1] 王智巍 王承 王施[1] 朱诚 

机构地区：[1]海军411医院神经外科,上海200081

出　　处：《中华神经外科杂志》2003年第1期26-29,共4页Chinese Journal of Neurosurgery

摘　　要：目的　了解国人胶质瘤中表皮生长因子受体基因 (EGFR)的扩增情况及对患者预后的影响。方法　使用半定量的DifferentialPCR方法对 1 1 3例福尔马林固定 石蜡包埋 (FFEP)胶质瘤标本内的EGFR基因扩增情况进行了检测 ;对其中的 83例进行了生存分析研究。结果　 1 1 3例胶质瘤中存在EGFR基因扩增的有 2 6例 ,其中低度恶性组中仅占 3 5 % ,而在高度恶性组中占 42 1 %。生存分析显示 :EGFR基因扩增对患者预后并无显著影响 ;而起病年龄、肿瘤病理分级、肿瘤生长部位及起病症状为失语对患者术后生存期有显著影响。结论　恶性胶质瘤中存在着较为广泛的EGFR基因扩增 。Objective To evaluate the incidence and prognostic significance of epidermal growth factor receptor (EGFR) gene amplification in Chinese gliomas. Methods 113 formalin fixed, paraffin embedded (FFPE) archival specimens were measured by differential PCR and 83 gliomas were investigated for a possible prognostic relevance.Results Amplification of the EGFR gene was detected in 26 of 113 gliomas. In that, only 3 5% in low grade and 42 1% in high grade gliomas were found. In survival analysis, the patients age, tumor grade, aphasia as initial symptom and location of the tumor were strong indicators of prognosis, and no correlation between EGFR gene amplification and survival was found.Conclusions Our data demonstrate that EGFR amplification is a frequent event in malignant gliomas, but it is not an independent prognostic factor.

关 键 词：胶质瘤 基因扩增 表皮生长因子受体 预后 

分 类 号：R739.4[医药卫生—肿瘤]