莪术油对小鼠肝癌细胞原位凋亡的影响  

Effect of Curcuma Aramatica Oil (CAO) on Cellular Apoptosis of Hepatoma Carried by Mice

作　　者：谭敏 宾晓农[2] 吴万垠 汪波 张维彬 肖楚梅 

机构地区：[1]广州中医药大学第二附属医院,510120 [2]广州医学院预防医学教研室

出　　处：《中西医结合肝病杂志》2002年第5期290-291,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:揭示莪术油对小鼠肝癌细胞凋亡的影响。方法:用莪术油进行2次小鼠肝癌体内抑制实验。以细胞原位凋亡TUNEL染色方法,评估莪术油对小鼠肝癌细胞凋亡的影响。结果:莪术油对小鼠肝癌细胞的抑癌率分别为51.85％和51.16％,与对照组相比有显著性差异(P<0.01);经莪术油作用过的小鼠HepA肝癌细胞的原位凋亡指数(AI)为6.64±1.26,与对照组2.32±0.82比较差异有显著性(P<0.01)。结论:莪术油抑制小鼠肝癌生长的机理可能与其诱导肝癌细胞凋亡有关。Objective: To reveal the effect of CAO on the cellular apoptosis of hepatoma carried by mice. Methods: After two inhibitory hepatoma experiments in vitro were conducted, the effect of CAO on cellular apoptosis of hepatoma carried by mice was evaluated by method of TUNEL. Results: The tumor inhibitory rates of CAO were 51.85% and 51.16% in two experimenets, respectively. Compared with those of the control groups, differences were statistically significant (P<0.01). In the group of mice treated with CAO, the index of apoptosis (AI) was 6.64±1.26, which was significantly higher than 2.30 ± 0.82 of the control group (P < 0.01). Conclusion: The inhibition of CAO on the growth of hepatic carcinoma carried by mice might be associated with its inducing cellular apoptosis.

关 键 词：莪术油 小鼠 肝癌 细胞凋亡 

分 类 号：R735.7[医药卫生—肿瘤]