复杂系统意义下的中医药学及其案例研究  

A Discussion and Case Study of Complexities in Traditional Chinese Medicine

作　　者：李梢[1] 王永炎[2] 季梁[1] 李衍达[1] 

机构地区：[1]清华大学生物信息学研究所,教育部生物信息学重点实验室,北京100084 [2]中国中医研究院,北京100700

出　　处：《系统仿真学报》2002年第11期1429-1431,1442,共4页Journal of System Simulation

基　　金：国家自然科学基金(30200365)

摘　　要：中医整体观、辨证论治体系所具有的系统大规模、开放于环境以及重视相互作用等特点,以及整体、活体、动态的观察方式是其复杂性的来源;通过对寒、热方剂作用的有关时间序列数据,1607例风湿病疼痛的节律性变化调查,中药方剂的最优配比等案例研究及分析,综合发现多种非特异性指标的特定组合、节律变动形式是寒热方剂、证候的系统特性之一。同时发现中药的总体效应不能用每一成分单独作用的线性叠加来表示,中药对复杂性疾病可发挥多因微效的综合调节作用。The complexities of traditional Chinese medicine (TCM) originates from the philosophy of integrality and symptom-differentiation, dynamic observation in vivo, and the interaction between system and its environment. In this study, the effects of cold and heat property Chinese herb on collagen induced arthritis rats, the rhythms of rheumatic pain in 1607 patients, and the analysis of the compatibility of Chinese herbal formula were presented as representatives. A bioinformatics method was used for data analysis. It was found that rhythm could characterize rheumatic diseases with different 揷old and heat syndromes in TCM. Furthermore, it was observed that the effect of herb mixtures could not be expressed by a linear summation of the effects of its ingredients. TCM can cure complex diseases that rooted in multiple factors by the integrated and composite regulation of tiny and multiple effects of its individual herbs.

关 键 词：复杂系统 中医药学 案例 复杂性 生物信息学 系统理论 

分 类 号：R22[医药卫生—中医基础理论] N941.4[医药卫生—中医学]