肿瘤显像剂^(99)Tc^m-HYNIC-TOC荷胰腺癌裸鼠的显像  

The Imaging of ^(99)Tc^m-HYNIC-TOC in Pancreatic Tumor Borne Nude Mice

作　　者：王正英[1] 杜延荣[1] 陈方[1] 欧阳萌[1] 李方[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院核医学科,北京100730

出　　处：《同位素》2002年第4期200-203,共4页Journal of Isotopes

摘　　要：进行了生长抑素受体显像剂99Tcm-HYNIC-TOC的正常小鼠体内分布、异常毒性及荷胰腺癌裸鼠的显像研究。正常小鼠及荷胰腺癌裸鼠的体内分布表明:该显像剂血液清除快,主要通过泌尿系统排泄。注射后1h肿瘤即显影,4h肿瘤与对侧肢体肌肉的T与NT摄取比达到7.7,此时肿瘤显像效果最佳。异常毒性实验表明99Tcm-HYNIC-TOC无异常毒性。The distribution of 99TcmHYNICTOC in mice and its imaging features in the SSRpositive pancreatic tumor borne in nude mice are investigated in detail. The results show that the blood radioactivity decreased rapidly and the tracer excretes mostly from the urinary tract after injection. SSRpositive pancreatic tumor borne in nude mice can be imaged 1 hour after injection and the image becomes optimal 3 hours later. The clear image indicates that the 99TcmHYNICTOC prepared in this experiment a very promising SSR tracer.

关 键 词：肿瘤显像剂 ^99Tc^m-HYNIC-TOC 荷胰腺癌 锝99 放射性同位素 标记 诊断 

分 类 号：R735.9[医药卫生—肿瘤] R730.[医药卫生—临床医学]