胰腺癌术后免疫治疗抗感染作用机制的探讨  

Role of Immunotherapy in Preventing Postoperative Infection in Patients with Pancreatic Cancer.

作　　者：虞先浚[1] 徐近[1] 傅德良[1] 张群华[1] 倪泉兴[1] 

机构地区：[1]复旦大学附属华山医院外科,200040

出　　处：《外科理论与实践》2003年第1期62-64,共3页Journal of Surgery Concepts & Practice

摘　　要：目的:了解免疫治疗剂胸腺肽鄄α1在胰腺癌术后抗感染中的作用机制。方法:选择60例胰腺癌根治术病人,分为用药组和对照组。用药组病人在手术后使用胸腺肽鄄α1,对照组不予使用。观察临床疗效、内毒素和细胞因子(IL鄄2、IL鄄6、IL鄄10和TNF鄄α)水平的变化,以及T淋巴细胞亚群CD3+、CD4+、CD8+和NK细胞百分率的变化。结果:胰腺癌手术组病人使用胸腺肽α鄄1后肿瘤坏死因子(TNF)鄄α水平明显下降,白介素(IL)鄄2、IL鄄10水平明显升高;手术后1周用药组的CD3+、CD4+百分率较手术前升高,且明显高于对照组。用药组术后1周临床有效率达100%,高于对照组(80%)。结论:胸腺肽鄄α1在胰腺癌术后可提高免疫力的功能,有利于病人恢复。Objective:To elucidate the mechanism of thymosinα1in preventing postoperative infection in patients with pancreatic cancer.Methods:Sixty patients with pancreatic cancer undergoing operation were divided into the thymosinα1treatment group and the control group.The level of endotoxin,IL2,IL6,IL10and TNFα,and the expression of CD 3+ ,CD 4+ ,CD 8+ and NK lymphocytes were investigated and clinical effects observed postoperatively.Results:In the treatment group,the level of TNFαdecreased and the levels of IL10and IL2increased significantly.The percentage of CD 4+ and CD 8+ lymphocytes was higher one week after operation in the treatment group than that of the control group.The clinical effects in the treatment group(100%)were also higher than that of the control group(80%).Conclusions:Thymosinα1may improve the immunological function of pancreatic cancer patients undergoing surgery and thus help their recovery.

关 键 词：胰腺癌 术后 免疫治疗 抗感染 作用机制 

分 类 号：R735.9[医药卫生—肿瘤] R730.51[医药卫生—临床医学]