前列腺癌组织中E-cadherin表达及与PSA的关系  

E-cadherin expression in prostate cancer and its correlation with PSA

作　　者：周利群[1] 黄啸[1] 吕英谦[1] 曾荔[1] 宓培[1] 夏同礼[1] 冯陶[1] 张志文[1] 那彦群[1] 郭应禄[1] 

机构地区：[1]北京大学第一医院北京大学泌尿外科研究所,100034

出　　处：《中华泌尿外科杂志》2003年第2期114-116,共3页Chinese Journal of Urology

基　　金：国家自然科学基金资助项目 ( 3980 0 173);国家教委留学回国人员科研启动基金资助项目

摘　　要：目的　探讨前列腺癌组织中上皮型钙粘附素 (E cadherin)表达及与PSA的关系。　方法　采用免疫组织化学染色法检测 5 6例前列腺癌组织标本E cadherin的表达 ,分析表达水平与总PSA(T PSA)、游离PSA(F PSA)及F/T值的关系。　结果　E cadherin正常表达 2 4例 ( 43 % ) ,异常表达3 2例 ( 5 7% ) ,E cadherin表达缺失与肿瘤恶性程度及分期呈正相关 (P <0 .0 1) ,与患者T PSA、F PSA无明显相关性 ,而与F/T值呈正相关 (P <0 .0 1)。　结论　EObjective To investigate the expression of E-cadherin in prostate cancer and its relationship with PSA. Methods E-cadherin expression of 56 prostate cancer samples were studied by immunohistochemical stain and its expression level was analyzed with respect to T-PSA, F-PSA and F/T ratio. Results 24 patients (43%) were normal and 32 patients (57%) were aberrant in E-cadherin expression. E-cadherin was related significantly to the grade and stage of cancer and the changes of F/T ratio.There were no significant relationship between E-cadherin expression and T-PSA or F-PSA. Conclusions E-cadherin expression may act as a marker to the malignant degree and the prognosis of the prostate cancer.

关 键 词：前列腺肿瘤 E钙粘附素 前列腺特异抗原 

分 类 号：R737.25[医药卫生—肿瘤]