喉大细胞神经内分泌癌  

Large cell neuroendocrine carcinoma of larynx

作　　者：房新志[1] 王振华[1] 柴敏秀[1] 

机构地区：[1]新疆医科大学附属肿瘤医院病理科,乌鲁木齐830011

出　　处：《临床与实验病理学杂志》2002年第6期592-594,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :探讨喉大细胞神经内分泌癌的临床及病理特征。方法 :复习 2例患者的临床病史、肿瘤组织的病理形态和免疫表型及相关文献。结果 :2例患者均为男性 ,以声音嘶哑、喉部不适为主要表现 ;病变均位于声门上 ,以具有丰富嗜酸性胞质、巢状排列为肿瘤细胞的形态特征 ;免疫组化表达神经内分泌肿瘤标志物。 2例均因短期内发生肿瘤广泛转移而死亡。结论 :喉大细胞神经内分泌癌属于高度恶性的肿瘤 ,形态上需与低分化鳞癌、甲状腺髓样癌、肺神经内分泌癌。Purpose To study the clinico pathological characteristic of large cell neuroendocrine carcinoma of the larynx. Methods With review of the literature, the clinical history, histopathological changes and immunohistochemical expression were investigated and reviewed in 2 cases of large cell neuroendocrine carcinoma of the larynx. Results Two cases were male, presenting complaints included hoarseness,discomfort in the throat. The lesions were involved in the supraglottis and characterized by cells with abundant eosinophilic cytoplasm, arranged in nests, expressed various markers of neuroendocrine carcinoma in immunohistochemistry. The two patients occurred widespread metastases and dead with the disease. Conclusions Large cell neuroendocrine carcinoma of the larynx has a poor survival. It needs to be differentiated from poor differentiated squamous cell carcinoma, pulmonary neuroendocrine carcinomas,laryngeal paraganglioma and amelanotic amelanoma in morphologically, and the immunohistochemical staining is helpful in differentiations.

关 键 词：喉肿瘤 神经内分泌 免疫组织化学 诊断 鉴别 

分 类 号：R739.65[医药卫生—肿瘤]