四种诱发大鼠运动病刺激模式的比较  

Comparison of Four Stimulation Patterns Inducing Motion Sickness

作　　者：付静宜[1] 孙祖玥[2] 于立身[3] 刘丽[1] 

机构地区：[1]空军总医院空军临床分子生物学中心实验室,北京100036 [2]吉林大学公共卫生学院卫生部放射生物学重点实验室 [3]空军航空医学研究所

出　　处：《吉林大学学报（医学版）》2003年第1期35-37,共3页Journal of Jilin University：Medicine Edition

基　　金：全军"十五"重点课题 ;空军后勤部"十五"规划项目 (0 1Z0 16 )

摘　　要：目的 :比较 4种刺激模式对运动病的诱发效应。方法 :将 60只雄性 SD大鼠随机分为对照组、三角形 组、三角形 组、梯形 组和梯形 组。以刺激前后食高岭土量为指标 ,对三角形 组和 组分别采用三角形刺激模式 (频率 0 .1 Hz,峰速 2 4 0°/ s)刺激 1 h和 1 .5 h,对梯形 组和 组分别采用梯形刺激模式 (加速度 1 0°/ s2 ,峰速 2 4 0°/ s,持续 5 min,减速至 0 )刺激 1 h和 1 .5 h,诱发运动病。结果 :在所用的 4种刺激模式中 ,三角形 组和梯形 组高岭土摄入量与对照组相比差异有显著性 ( P<0 .0 1 ) ,梯形 组与对照组相比差异有显著性 ( P<0 .0 5 )。同时三角形 组和梯形 组高岭土摄入量与三角形 组比差异也有显著性 ( P<0 .0 5 )。结论 :用三角形 组或梯形Objective: To compare the effect of four stimulation patterns inducing motion sickness. Methods:Sixty male SD rats were assigned randomly to the five treatment groups. Using triangle stimulation pattern (frequency: 0.1 Hz, peak speed: 240°/s) and trapezoid stimulation pattern (acceleration: 10°/s 2, peak speed:240°/s during 5 min,then decelerated to 0) to induce motion sickness. The rats were stimulated for 1 h in triangle Ⅰ and trapezoid Ⅰ groups and for 1.5 h in triangle Ⅱ and trapezoid Ⅱ groups. The kaolin intake of rats was measured before and after stimulation. Results: As compared with control group, the amount of kaolin intake was significantly increased in triangle Ⅱ and trapezoid Ⅰ groups ( P <0.01) and in trapezoid Ⅱ group ( P <0.05). As compared with triangle Ⅰ group, the amount of kaolin intake was significantly increased in triangle Ⅱ and trapezoid Ⅰ groups ( P <0.05). Conclusion: The stimulation pattern in triangle Ⅱ and trapezoid Ⅰ groups is more effective to induce motion sickness.

关 键 词：晕动病 病因学 刺激模式 高岭土 疾病模型 动物 

分 类 号：R－332[医药卫生] R852.33