帕罗西汀对卒中后抑郁P_(300)的影响  

Effect of Eevent Related Potential in Post-stroke Depression with Paroxetine

作　　者：宋永斌[1] 郝玉洁[1] 徐江涛[1] 郝舒亮[1] 

机构地区：[1]兰州军区乌鲁木齐总医院神经内科,830000

出　　处：《神经疾病与精神卫生》2003年第1期40-41,共2页Journal of Neuroscience and Mental Health

摘　　要：目的　通过对卒中后抑郁 (PSD)患者帕罗西汀治疗前后P30 0 的研究 ,探讨PSD患者认知损害的发生机制。方法　选择符合第 2版《中国精神障碍诊断标准》的 4 6例PSD患者 ,其中脑梗死 2 9例 ,脑出血 17例。治疗前后均经汉密尔顿抑郁量表 (HAMD) ,简易精神状态检查法 (MMSE)及听觉oddball刺激序列事件相关电位 (P30 0 )检测。t -test检验结果显示治疗前后均数有显著性差异。结果　治疗后PSD患者P3潜伏期显著缩短 (P <0 .0 1)且波幅显著增高 (P <0 .0 5 ) ;治疗前后PSD患者MMSE具显著性差异 (P <0 .0 5 )。结论　PSD患者的认知损害可能与 5Objective To evaluate the event related potential (ERP or P 300 ) in post-stroke depression (PSD) with paroxetine and investigate the possible mechanism of cognitive dysfunction in PSD.Methods 46 cases of patients with stroke (29 patients with cerebral infarction, 17 patients with cerebral hemorrhage) who met diagnosis standard for PSD of The Chinese Classification and Diagnostic Criteria for Mental Disease (the Second Revised Edition, CCMD-2) were assessed by HAMD and MMSE scale before and after treatment. P 300 was investigated. The results were analyzed with t-test. Results The P3 latency in the PSD group was significantly decreased after treatment (P<0.01). And the amplitude of P 3 was significantly increased in the PSD group(P<0.05).MMSE scale were significant difference (P<0.05).Conclusions The cognitive dysfunction of the PSD patients possible mechanism is abnormal of 5-HT.

关 键 词：脑血管意外 抑郁症 事件相关电位 

分 类 号：R749.1[医药卫生—神经病学与精神病学]