胰头和壶腹部癌微血管定量分析与临床病理研究  

Angiogenesis in periampullary carcinoma

作　　者：卫文栋[1] 孙家邦[1] 李非[1] 王居玢[2] 刘青光[2] 于良[2] 

机构地区：[1]首都医科大学宣武医院普外科,100053 [2]西安交通大学第一医院普外科,710061

出　　处：《临床和实验医学杂志》2002年第4期224-227,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的　通过测定胰头和壶腹部癌肿瘤和癌周组织微血管密度 ,分析其与常规临床病理参数的关系及在预后中的意义。方法　在对 6 7例胰头和壶腹部癌患者回顾性调查的基础上 ,采用免疫组织化学和常规病理学方法 ,并借助自动图像分析技术 ,半定量测定肿瘤和癌周组织微血管密度。结果　①高分化癌微血管计数明显低于低分化癌 (P <0 0 1) ;肿瘤直径 <3cm者微血管计数明显低于直径≥ 3cm者 (P <0 0 5 ) ;②有区域淋巴结内癌转移者微血管计数明显高于无区域淋巴结内癌转移者 (P <0 0 1) ;③非整倍体肿瘤的微血管计数明显高于整倍体肿瘤 (P <0 0 5 ) ;④随着肿瘤微血管密度的增加 ,术后生存率呈下降趋势 ,而复发和转移率却呈上升趋势。结论①胰头和壶腹部癌微血管密度是其他临床病理参数的有益补充 ;②微血管密度与预后关系密切 。Objective Analyses the relationship between microvessel density (MVD) and usual pathological parameters,and evaluate it's prognostic significance Methods Sixty seven patients with periampullary carcinoma were recruited in the retrospective study,immunohistochemical staining,usual pathologic staining and automatic imaging analysis technique were adopted to determine MVD semiquantitatively Results (1)Microvessel count(MVC) in tumor tissue was less in high-differentiated tissue than in low-differentiated one( P <0 01) and less in tumor's diameter <3cm than in ≥3cm (P≤0 05) (2)MVC of tumor tissue was higher in those with metastasis of regional lymph node than in those without metastasis( P <0 01) (3) MVC in aneuploid tumor was higher than in diploid tumor( P <0 05) (4) When MVD increased,the overall survival rate after operation decreased and the risk of recurrence and metastasis increased Conclusion In periampullary carcinoma,(1)MVD is a significant clinical pathologic parameter,(2) MVD is related to the prognosis and helpful in predicting the prognosis

关 键 词：壶腹部癌 微血管定量分析 临床 病理研究 胰头癌 微血管密度 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]