Immunological changes of chicken infected with marek's disease virus  

作　　者：Liu Zhonggui Li Qingzhang Gao Rong Liu Yun Zheng Shimin Yang Liping(Animal Medicine Department, Northeast Agricultural University,Harbin 150030,P.R.China) 

出　　处：《Journal of Northeast Agricultural University(English Edition)》1994年第1期33-41,共9页东北农业大学学报（英文版）

摘　　要：The experiment was conducted to infect one-day old healthy AA chicks with virulent Marek'sdisease virus(MDV).Compared with the uninfected control chicks,it was undertaken to detect theinductive activity of interlukin-2,expression of IL-2 recepter(IL-2R)and proliferative reaction ofT cell in the thymus and spleen;to determine the number of α-naphthyl esterase positive T cells,acid phosphatase positive T cells and antibody forming cells in the thymus,Bursa Fabricius,spleen,cecal tonsil, Harder gland and mucosal lympoid tissue of bronchus;to check the number of T cell inperipheral blood as well as the dynamic changes of the amount of IgG, IgM and IgA in the serum,tear, trachea washings and intestinal secretions of infected chickens at 5,25,45 days old,respectively.The experimental results reveal that immunoregulation of IL-2 in immune organs ofinfected chickens was disordered;the cellular and humoral immune functions weresignificantly depressed in the central and peripheral immune organs;the local or mucosal immunedefense function were also markedly decreased in respiratory and digestive tracts.The experiment was conducted to infect one-day old healthy AA chicks with virulent Marek'sdisease virus(MDV).Compared with the uninfected control chicks,it was undertaken to detect theinductive activity of interlukin-2,expression of IL-2 recepter(IL-2R)and proliferative reaction ofT cell in the thymus and spleen;to determine the number of α-naphthyl esterase positive T cells,acid phosphatase positive T cells and antibody forming cells in the thymus,Bursa Fabricius,spleen,cecal tonsil, Harder gland and mucosal lympoid tissue of bronchus;to check the number of T cell inperipheral blood as well as the dynamic changes of the amount of IgG, IgM and IgA in the serum,tear, trachea washings and intestinal secretions of infected chickens at 5,25,45 days old,respectively.The experimental results reveal that immunoregulation of IL-2 in immune organs ofinfected chickens was disordered;the cellular and humoral immune functions weresignificantly depressed in the central and peripheral immune organs;the local or mucosal immunedefense function were also markedly decreased in respiratory and digestive tracts.

关 键 词：vMDV infection CHICK IMMUNOREGULATION immune function 

分 类 号：S858.315.3[农业科学—临床兽医学]