血清可溶性细胞间粘附分子-1与胃癌临床意义的研究  

Significance of soluble intercellular adhesion molecule-1expression in serun of patients with gastric carcinoma

作　　者：倪海滨[1] 毛振彪[2] 黄介飞[2] 肖明兵[2] 季颖林[2] 张彦亮[2] 冒海蕾[2] 

机构地区：[1]南京医科大学附属南京市第一医院,南京210006 [2]南通医学院附属医院内科

出　　处：《南通医学院学报》2003年第1期54-55,57,共3页ACTA Academiae Medicinae Nantong

摘　　要：目的 :研究胃癌患者外周血中可溶性细胞间粘附分子 - 1( s ICAM- 1)的水平与胃癌临床病理特征的关系。方法 :通过酶联免疫吸附试验测定比较 15例正常健康人及 6 0例胃癌患者手术前后 1周外周血中 s ICAM- 1浓度的变化。结果 :胃癌组外周血清中 s ICAM- 1的浓度 ( 14 2 .2 2± 2 1.5 8) ng/ ml与正常组 ( 6 0 .95± 19.39) ng/ ml比较差异有显著性 ( P<0 .0 1)。术后胃癌患者 ( n=15 )血清 s ICAM- 1的浓度较术前明显下降 ( P<0 .0 1) ,胃癌血清 ICAM- 1的表达水平与胃癌浸润深度、淋巴结转移、TNM分期密切相关。结论 :检测胃癌血清 ICAM- 1的表达水平对评估胃癌侵袭深度、淋巴结转移程度、TNM分期及复发有较大意义 ,s ICAM-Objective:This study was to determine the serun level of soluble intercellular adhesion molecule-1(sICAM-1) in patients with gastric carcinoma and to elucidate the relation of its level with clinical characteristics and metastasis of gastric cancer.Methods:The serun levels of soluble ICAM-1 were measured with enzyme linked immunosorbent assay in 15 healthy controls and 60 patients with gastric cancer before and after operation.Result:Serun concentration of sICAM-1 was significantly elevated in the patients with gastric cancer(142.22±21.58ng/ml)in compared with healthy control subjects(60.95±19.39ng/ml)(P<0.01) ,and the levels of postoperative(n=15) sICAM-1 was significantly lower than preoperative's(154.35±15.67ng/ml)(P<0.01). The level of sICAM-1 expression were closely correlated with invasion deep,with TNM stage,with lymph node metastasis.Conclusion:Examination of sICAM-1 in gastric cancer helps a lot in evaluating intensity of lymph node metastasis,TNM stage and prognosis. sICAM-1 might be valuable marker in assessing invasion and metastatic potential of gastric carcinoma.

关 键 词：胃癌 可溶性细胞间粘附分子-1 酶联免疫吸附试验 侵袭转移 

分 类 号：R735.2[医药卫生—肿瘤]