米非司酮对子宫肌瘤超微结构的影响  

The effects of mifepristone on ultrastructure of uterine leiomyoma.

作　　者：喇端端[1] 吴步初[1] 季晓琼[1] 沈立翡[1] 龙雯靖[1] 

机构地区：[1]上海第二医科大学附属瑞金医院妇产科,200025

出　　处：《中国实用妇科与产科杂志》2003年第2期95-96,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨米非司酮对子宫肌瘤超微结构的作用。方法　随机选择子宫肌瘤患者 2 4例 ,连续服用米非司酮 2 5mg或 12 5mg ,12周后行子宫切除术 ,取子宫标本 ,在电镜下观察肌瘤超微结构变化。并随机选择 6例未用药的子宫肌瘤患者 ,同样方法取标本进行比较。结果　米非司酮可使肌瘤细胞及血管不同程度的退行性改变。Objective To study the effects of mifepristone on ultrastructure of uterine leiomyoma.Methods Mifepristone 25mg or 12 5mg/d was given each of random 24 patients with uterine leiomyoma and 12 weeks later total hysterectomy was done and examine the ultrastructure of leiomyoma with electron microscope.6 patients not given any drugs with uterine leiomyoma were administrated in comparison.Results We found mifepristone degenerate the leiomyoma cells and small blood vessels.Conclusion Uterine leiomyoma can be treated with mifepristone.

关 键 词：米非司酮 子宫肌瘤 超微结构 治疗 

分 类 号：R737.33[医药卫生—肿瘤]