符合线路SPECT^(18)F-FDG显像用于乳腺癌诊断及分期的初步结果  

Study on the Diagnosis and Staging of Breast Cancer with ^(18) F-FDG Coincidence Imaging

作　　者：范岩[1] 付占立[1] 胡怀湘[1] 赵建新[2] 赵光宇[1] 王荣福[1] 

机构地区：[1]北京大学第一医院核医学科,北京100034 [2]北京大学第一医院外科,北京100034

出　　处：《中国医学影像技术》2003年第2期192-194,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的　探讨符合线路SPECT 18F FDG显像在乳腺癌诊断及分期中的临床应用价值。方法　经组织学确诊的乳腺癌患者共 17例 ,术前及术后行18F FDG显像检查的患者分别为 9例和 8例。检查前患者禁食 6h以上 ,静脉注射18F FDG111～ 15 9.1MBq 1h后进行显像。图像经迭代法重建 ,并计算病灶与对侧相应部位或邻近正常组织的放射性计数比值 (T/B)。结果　乳腺原发恶性病灶 11个 ,18F FDG显像均可见局限性放射性异常浓聚 ,T/B值为 1.3 5～ 4.5 2 ;腋窝淋巴结转移灶 19个 ,18F FDG显像发现其中 5个有18F FDG摄取增高 ,T/B值为 1.3 7～ 2 .0 6。 5例18F FDG显像发现远处转移灶 ,2例患者18F FDG检查未见明显异常 ,结果与骨显像、超声、CT及MRI一致。 2个良性病灶CT和超声考虑为转移灶 ,而18F FDG显像未见FDG摄取增加。结论　符合线路SPECT18F FDG显像在乳腺癌诊断及分期方面有较好的临床应用价值 ,对肿物定性诊断优于CT和超声检查 ,但对腋窝淋巴结转移灶的检出率较低。Objective To assess the value of 18 F FDG coincidence imaging in the diagnosis and staging of breast cancer. Methods Seventeen patients with breast cancer underwent 18 F FDG coincidence imaging pre or post operations. The patients fasting over 6h were performed with coincidence SPECT following 60min postinjection of 111-159.1 MBq of 18 F FDG. The images were reconstructed iteratively,and the count ratios of tumor to background (T/B) were calculated. Results All of the 11 primary breast lesions were identified by increased FDG uptake. The T/B ratios were 1.35-4.52 (2.40± 0.94 ). The sensitivity of coincidence SPECT for axillary lymph node metastases was 26.3% (5/19),T/B ratios were 1.37-2.06(1.67±0.27). Distant metastases were detected in 5 patients by the coincidence SPECT. The same results were found in CT,ultrasound or bone imaging. 18 F FDG images were normal in 2 patients,and no abnormal found in CT,MRI or ultrasound. It's showed no high FDG uptake in 2 benign lesions,while CT and ultrasound indicated them metastasis. Conclusion 18 F FDG coincidence imaging is a useful diagnostic test for detecting primary and metastatic lesions of breast cancer. Its specificity is superior to that of CT and ultrasound. But the sensitivity of coincidence SPECT for detecting axillary lymph node metastases was low.

关 键 词：^18F-FDG符合线路显像 乳腺癌 诊断 分期 临床应用 

分 类 号：R730.44[医药卫生—肿瘤] R737.9[医药卫生—临床医学]