用拉曼光谱研究抗癌药物落羽松醇和它的类似体  

Raman Spectroscopic Investigation of taxol and Its Analogues

作　　者：郑思定[1] 舒莲美 洪田博喜 

机构地区：[1]复旦大学分析测试中心,日本岗山理科大学

出　　处：《光散射学报》1995年第2期145-150,共6页The Journal of Light Scattering

摘　　要：用拉曼光谱研究抗癌药物落羽松醇和它的类似体郑思定，舒莲美，洪田博喜（复旦大学分析测试中心上海２００４３３）（日本岗山理科大学）ＲａｍａｎＳｐｅｃｔｒｏｓｃｏｐｉｃＩｎｖｅｓｔｉｇａｔｉｏｎｏｆｔａｘｏｌａｎｄＩｔｓＡｎａｌｏｇｕｅｓ￥ＺｈｅｎｇＳｉｄ...Abstract The novel diterpenoid taxol has become one of the most important anticancer agents. In this article we have measured the Raman spectra of taxol and 1 0．deacetylbaccatin Ⅲ． The assignment of the spectra have been given.Wefound that taxol and 1 0－deacetvlbaccatin Ⅲ are different in side chain.Therefore the spectra of two samples was very similar， The characteric line of taxol is l648cm^(_1) which can be assigned to amide Ⅰ．Many information can be got from these Raman spectra， This suggests that the composition of taxol may be identified by Raman spectroscopy.

关 键 词：拉曼光谱 抗癌药物 落羽松醇 类似体 天然药物 药物分析 TAXOL 分子结构 活性部位 

分 类 号：R979.1[医药卫生—药品] R282.71[医药卫生—药学]