聚集素在前列腺正常、增生、癌组织中的表达及意义  

Expression and significance of clusterin in normal prostate,benign prostate hyperplasia and prostate cancer

作　　者：周利群[1] 杨学贞[1] 曾荔[1] 梁丽莉[1] 杨新宇[1] 任亮[1] 李钟 张志文[3] 那彦群[1] 顾方六[1] 郭应禄[1] 

机构地区：[1]北京大学第一医院泌尿外科研究所,100034 [2]DepartmentofUrology,NorthwesternUniversityMedicalSchool [3]北京大学生理学系

出　　处：《中华外科杂志》2003年第2期93-95,共3页Chinese Journal of Surgery

基　　金：国家自然科学基金资助项目 (3980 0 173);国家教委留学归国人员科研启动基金资助项目 (1998 2 0 0 0 )

摘　　要：目的　通过检测聚集素 (Clusterin)在前列腺正常、增生、癌变组织中的表达 ,探讨其与前列腺疾病发生发展的关系。　方法　采用免疫组织化学染色法检测 12例正常前列腺组织、15例良性前列腺增生组织 (BPH)、5 6例前列腺癌标本中Clusterin的表达水平。　结果　 3种组织中Clusterin的阳性及弱阳性表达率为 81% (67/83 ) ,其中前列腺正常、增生、癌组织中阳性及弱阳性表达率分别为17% (2 /12 )、73 % (11/15 )、96% (5 4/5 6)。前列腺癌组织中Clusterin表达水平明显高于前列腺正常 (t=8 82 ,P <0 0 1)及增生 (t =7 63 ,P <0 0 1)组织 ,且在癌组织中与肿瘤病理分级 (r =0 64 9,P <0 0 1)、临床分期 (r=0 60 9,P <0 0 1)呈正相关。Objective To investigate the expression and significance of Clusterin in normal prostate、benign prostate hyperplasia (BPH) and prostate cancer. Methods Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain. Results Of 83 cases, 67 are positive or weak positive(81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17%(2/12)、73%(11/15), and 96%(54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate ( t =8 82, P < 0 01). BPH( t =7 63, P < 0 01) was related positively with pathological grade( r =0 649, P < 0 01) and stage ( r =0 609, P < 0 01)of prostate cancer. Conclusion Clusterin may play an important role in the biological characteristics of prostate cancer by the antiapoptosis pathway.

关 键 词：前列腺肿瘤 脱噬作用 癌 CLUSTERIN 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]