Effect of H_1 antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats  

组胺H_1受体阻断剂对大鼠八臂迷宫空间记忆的影响<英文>

作　　者：陈忠[1] 陈季强[1] 龟井千晃 

机构地区：[1]浙江大学医学院基础医学系药理学研究室,杭州中国310031 [2]日本国立冈山大学药学部药理学教室

出　　处：《Acta Pharmacologica Sinica》2001年第7期609-613,共5页中国药理学报（英文版）

摘　　要：ATM: To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats. METHODS: Eight-arm radial maze performance was used to measure spatial memory in rats. RESULTS: Chronic treatments of classical H1-antagonists, diphenhydramine (5 mg/kg) and pyrilamine (20 mg/kg) impaired acquisition memory process regarding both parameters of radial maze performance, In addition, the memory retrieval process was also impaired significantly by a single administration of diphenhydramine (5, 10 mg/kg) and pyrilamine (50 mg/kg). However, the newly developed H1antagonist, epinastine caused no appreciable effect on both acquisition and retrieval memory even at a high dose of 50 mg/kg. The memory deficit induced by diphenhydramine (10 mg/kg) or pyrilamine (50 mg/kg) was reversed by tacrine (1 mg/kg). CONCLUSION: Histamine H1-receptors plays a certain role in spatial cognition, and its action may be due to both histaminergic and cholinergic neurons.目的:研究和阐明组胺H_1受体阻断剂对大鼠空间记忆的作用机制。方法:采用八臂迷宫学习的程序研究大鼠的空间记忆。结果:在学习过程中,腹腔内注射第一代组胺H_1受体阻断剂苯海拉明(5mg/kg)或美吡拉明(20mg/kg)显著性地引起空间记忆障碍。苯海拉明(5,10mg/kg)、美吡拉敏(50mg/kg)则浓度依赖性且显著性地引起空间记忆再生过程的障碍。相反,新型组胺H_1受体阻断剂依匹斯汀(50mg/kg)对大鼠的学习和记忆再生过程均无明显作用。他克林(1mg/kg)可改善苯海拉明(10mg/kg)、美吡拉敏(50mg/kg)所致的记忆障碍。结论:中枢组胺H_1受体参与了调节大鼠空间记忆的作用,而且其作用主要与组胺神经及胆碱能神经相关。

关 键 词：maze learning histamine H  receptors PYRILAMINE DIPHENHYDRAMINE EPINASTINE TACRINE 

分 类 号：R96[医药卫生—药理学]