线粒体DNA ND-1基因点突变与2型糖尿病的关系  

The association of ND-1 gene point mutations of mit ochondrial DNA with type 2 diabetes mellitus

作　　者：钱杰[1] 张丽容[1] 

机构地区：[1]东南大学附属中大医院心内科,南京210009

出　　处：《中华内分泌代谢杂志》2003年第1期46-47,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：2型糖尿病患者中线粒体DNA(mtDNA) 331 6G→A、3394T→C突变频率分别为 3 .9% (6/1 52 )和 5 .3 % (8/ 1 52 ) ,显著高于正常对照者及冠心病患者。提示mtDNA 331 6G→A、3394T→G突变与 2型糖尿病相关。In type 2 diabetic patients the f re quencies of point mutations 3316G→A and 3394T→C in mitochondrial DNA (mt DNA) were 3.9% (6/152) and 5.3% (8/152) respectively, which were significantly higher than those in normal controls and patients with coronary heart disease. This fi nding suggests that mtDNA 3316G→A and 3394T→G mutations are related to type 2 diabetes.

关 键 词：线粒体DNA 点突变 非胰岛素依赖型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]