含氨基聚甲基丙烯酸羟乙酯树脂对胆红素的吸附性能研究  

Studies on Adsorption of Bilirubin by Crosslinking Poly(2-hydroxyethyl methacrylate) Adsorbents Containing Amino Group

作　　者：卢玲[1] 袁直[1] 石可瑜[1] 何炳林[1] 刘斌 沈彬 王起顺 

机构地区：[1]南开大学高分子化学研究所 [2]天津市高等医学专科学校,天津300052

出　　处：《高等学校化学学报》2003年第3期454-458,共5页Chemical Journal of Chinese Universities

基　　金："973"计划项目 (批准号 :G19990 6470 7)资助

摘　　要：以交联聚甲基丙烯酸羟乙酯树脂为载体 ,以己二胺和多乙烯多胺为功能基制备了一系列胆红素吸附剂 ,研究了它们在不同吸附温度、离子强度和胆红素浓度等条件下 ,对胆红素的吸附性能的影响 .研究表明 ,该类吸附剂对胆红素具有良好的吸附性能 。Adsorbents for bilirubin were prepared by immobilizing amino group on crosslinking poly(2-hydroxyethyl methacrylate)(PHEMA) resins. The effects of adsorption temperature, ion strength, bilirubin concentration and human serum albumin on the adsorption properties for bilirubin were studied. It was shown that, this kind of adsorbent had a good adsorption efficiency and high adsorption capacity, and the adsorption performances of resins immobilizing hexanediamine and protonized hexanediamine were better than others. When adsorption temperature rose from 20 ℃ to 45 ℃, the adsorption percentage of resins immobilizing hexanediamine and protonized hexanediamine for bilirubin increased slightly, while that of resins immobilizing triethylenetetraamine increased below 37 ℃ and decreased above 37 ℃, which could be due to the stronger interaction between hexanediamine and bilirubin than that between triethylenetetraamine and bilirubin. The adsorption percentage decreased when ion strength increased. With the increase of the concentration of bilirubin in solution, the adsorption percentage decreased while the adsorption capacity increased. When the concentration of bilirubin was 750 mg/L, the adsorption percentage of resins bearing hexanediamine was near 80% and that of resins bearing protonized hexanediamine was over 90%, and the adsorption capacity were 29.84 mg/g and 34.60 mg/g respectively. Resins immobilizing hexanediamine and protonized hexanediamine could also adsorb bilirubin in the presence of albumin. The adsorption of bilirubin by the PHEMA adsorbents containing amino groups could be attributed to the interaction between amino groups on adsorbents and carboxyl groups in bilirubin and also the hydrophobic interaction and hydrogen bonds.

关 键 词：氨基 聚甲基丙烯酸羟乙酯树脂 胆红素 吸附性能 高胆红素血症 治疗 血液灌流 

分 类 号：R575.6[医药卫生—消化系统] R457[医药卫生—内科学]