2-巯基-5-甲氧基-1H-苯并咪唑的合成工艺改进  

A New Synthetic Method of 2-mercapto-5-Methoxy-1H-enzimidazole

作　　者：刘德龙[1] 刘蕴[1] 胡涛[1] 戴桂元[1] 

机构地区：[1]徐州师范大学化学系,江苏徐州221116

出　　处：《徐州师范大学学报（自然科学版）》2002年第4期68-70,共3页Journal of Xuzhou Normal University(Natural Science Edition)

摘　　要：以扑热息痛为原料,经甲基化、硝化、水解得到2 硝基 4 甲氧基苯胺,以水合肼还原后,再与乙基黄原酸钾环缩合得2 巯基 5 甲氧基 1H 苯并咪唑,总收率达66 7%.Paracemol was methylated, nitrified and hydrolyzed to give N(2nitro4methoxy)phenyldiamine which was reducted then in the presence of hydrazine hydrate. 5Methoxy2benzimidazolethiol was synthesized via cyclocondensation reaction of 4methoxy1,2benzenedoamine with potassium ethyl xanthate in the overall yield of 667%.

关 键 词：2-巯基-5-甲氧基-1H-苯并咪唑 合成工艺 扑热息痛 水合肼 药物中间体 奥美拉唑 抗溃疡药物 

分 类 号：R975.6[医药卫生—药品] TQ460[医药卫生—药学]